Inflammation and cancer
Prof. Mads Gyrd-Hansen
We study molecular mechanisms governing pro-inflammatory signalling during innate immune responses. Through this, we aim to understand the molecular events that on one hand protect against pathogens, but also contribute to chronic inflammation, tumour development, growth and metastasis. A central focus of the lab is to elucidate the role and regulation of ubiquitin modifications that control inflammatory signalling during these processes. Ultimately, we aim to identify ubiquitin-handling factors that can be targeted to modulate inflammation and antagonize cancer.
Our work focuses primarily on studying signalling events and cellular responses triggered by bacteria and cytokines in macrophages and epithelial cells. We use biochemistry and molecular and cell biology, together with mass spectrometry-based proteomics, transcriptomics and bioinformatic analyses, to study how the ubiquitin system controls fundamental processes of the immune system. To broaden the scope of our research, we collaborate with researchers who have complementary expertise, including structural biologists, mass spectrometry experts and clinical researchers.