Registration is now open for the 11th European workshop on cell death to be held in Fiuggi, Italy from 6-11th May 2018. The meeting, co-organised by Ludwig researcher Mads Gyrd-Hansen, will focus on cell death, inflammation and cancer, and the participation of younger scientists (PhD students and post-docs) in addition to PIs is encouraged. Apply online by 15th January 2018.
Several Ludwig Institute researchers spoke at the Oxford transcription and chromatin meeting on 7-8th December 2017 at the Oxford Martin School. Xin Lu, Sarah De Val, Colin Goding, David Mole, Chunxiao Song and Skirmantas Kriaucionis all presented research stories from their labs that are related to transcription, the process by which an RNA molecule is produced using DNA as a template. Xin Lu’s lab studies the transcriptional regulator ...
Would you like to join Ludwig Oxford as a graduate student in October 2018? Applications are currently invited for the NDM Prize Studentships - the deadline is 8th January 2018. The wide range of exciting projects at Ludwig are highlighted in our Jobs and Study section. Candidates are judged on the basis of their academic and research potential.
Mutation of a cytosine (C) DNA base to a thymine (T) base is more likely to occur if the C is followed by a guanine (G) and if the C is chemically modified by methylation. This was thought to be mainly due to the spontaneous deamination of methylated C to T. A new study in DNA Repair by Tomkova and colleagues from the labs of Benjamin Schuster-Böckler and Skirmantas Kriaucionis demonstrates that errors introduced during replication may also have a role in the increased mutability of methylated cytosine to thymine.
DPhil student Ruoshi Peng from Mads Gyrd-Hansen’s lab won a prize for a poster she presented at the EMBO Young Investigator’s PhD course in Heidelberg, Germany. In her poster, Ruoshi highlighted a technique she is using to study regulatory proteins modified by chains of small proteins called ubiquitin. Because ubiquitin chains are often very short-lived, these modifications have previously been very difficult to study. However, with this new technique, Ruoshi can investigate the function of ubiquitin chains to understand their role in the regulation of inflammatory cell death.
DPhil student Emma Fenech from John Christianson’s group won a prize for the poster she presented at the EMBO conference on Proteostasis in Ericeira, Portugal. Her research focuses on mapping the molecular interactions of protein machines called ubiquitin ligases that add ubiquitin, a small regulatory protein, to other proteins. One of these ubiquitin ligases is known to regulate signalling in the immune system and she demonstrated that the interactions this ligase makes are important for controlling the immune response.
Dr Benjamin Schuster-Böckler was selected as a panellist to discuss ‘Fostering best practice in Research Integrity’ at the SpotOn (science policy outreach and tools online) London event on 18th November 2017. Ben highlighted the initiatives we are using to maintain a high standard of Research Integrity at the Ludwig Institute.
Learn about the latest research into how cells use chains of ubiquitin – a small protein regulatory protein – to control innate immune signalling in a new review in Molecular Cell by Ludwig’s Mads Gyrd-Hansen and Matous Hrdinka. Their review focuses on how ubiquitin chains are tightly regulated and the consequences of deregulation in human diseases.
When proteins are formed inside cells they have to fold in the correct 3D structures to function correctly. Too many misfolded proteins can be toxic to the cell, so there are molecular mechanisms that help to clear away potentially dangerous protein forms. A new study in Journal of Cell Science from John Christianson’s group at Ludwig Oxford has identified a specific domain in protein called Hrd1 that is crucial for the clearance machinery in the endoplasmic reticulum.
The prestigious Myron Gordon Award is presented once every three years at each International Pigment Cell Conference to recognize one or more scientists for distinguished and outstanding contributions to the pigment cell biology field. In 2017 the joint awardees were Colin Goding from Ludwig Oxford, and Emi Nishimura, Tokyo Medical and Dental University Japan. The awards were announced at the recent International Pigment Cell Conference held in ...