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News

A group photo showing, from left to right: Benoit Van den Eynde, Jedd Wolchok, Hannah Fuchs, Xin Lu, Benjamin Schuster-Boeckler, Nickolas Papadopoulos and Pat Morin.

Ludwig Oxford at 2024 AACR

Lu Ratcliffe Schuster-Böckler Van den Eynde White

Ludwig Oxford staff and students alike share their research in San Diego at the 2024 AACR Annual Meeting

Photo of leadership fellow Francesco Boccellato with dark hair and brown eyes, turning to face the camera and wearing a dark blue jacket

Francesco Boccellato receives esteemed Lee Placito Research Fellowship

Boccellato

Ludwig Oxford’s Francesco Boccellato has received the prestigious Lee Placito Research Fellowship in Gastrointestinal Cancer.

Ludwig Cancer Research logo

Vacancy: Research Assistant - Computational

Jobs Lu Schuster-Böckler

£32,332 - £38,205 with a discretionary range to £41,732 p.a. (pro rata)

Marketa Tomkova (centre) receiving her award with the director of Czekpats in Science Matouš Glance and board member Markéta Icha Kubánková.

Ludwig Oxford’s Marketa Tomkova is the first recipient of the Czexpats in Science Award

Tomkova

Ludwig Oxford’s Marketa Tomkova has been awarded the very first Czexpats in Science Award for her success in the field of genomics and DNA sequencing

Ludwig Cancer Research logo

Vacancy: Senior Postdoctoral Scientist – Tumour immunology

Jobs Van den Eynde

Grade 8: £45,585 - £54,395 with a discretionary range to £59,421 p.a.

Ludwig Cancer Research logo

Vacancy: Laboratory Technician

Jobs Song

Grade 5: Salary in range £28,759 - £33,966 per annum

Early events following von Hippel Lindau inactivation shape the trajectory of cancer initiation in the kidney

Work from the Ratcliffe research group demonstrates the early events defining the cell-type specificity of oncogenesis, providing a focus for mechanistic understanding and therapeutic targeting.

Ludwig Oxford’s Helen Byrne recognised as an Honorary Doctor at Chalmers 2024

Byrne

Ludwig Oxford’s Helen Byrne has been recognised for her contributions and major efforts in the field of mathematical biology

Table set up showing the decoding sentence game described in the news story. A set of rotatable blocks each displaying DNA codons are threaded on a tube and a magnetic board above with the corresponding amino acid letter to the codon spells out the sentence. By rotating the blocks, the participant can change the sentence letter by letter to see how a mutation may affect a coding gene.

Ludwig Oxford enjoys time at Abingdon ATOM Festival of Science and Technology

Public Engagement

Ludwig Oxford volunteers head to Abingdon ATOM Festival to run a stall discussing genetic mutation and cancer detection

A collage of photos of female PIs and group leaders in Ludwig Oxford. From left to right: Pari Mehdipour, Xin Lu, Marketa Tomkova, Helen Byrne, Bethan Psaila, Sarah De Val, Ellie Barnes, Tammie Bishop and Carol Leung

International Women's Day within Ludwig Oxford

Barnes Byrne De Val Lu Mehdipour Ratcliffe Tomkova Van den Eynde

The 8th March annually celebrates Women's achievements and we are delighted to celebrate the women researchers, students and staff within Ludwig Oxford

Compilation of microscopy images from Figure 7c of the paper showing a variety of dual immunofluorescence staining. For full image details, please see the figure legend in the full paper.

Factor-inhibiting HIF deficiency is found to create a tumour-promoting immune microenvironment

Lu Ratcliffe

A collaborative study by the Lu and Ratcliffe research groups has found that the tumour-promoting immune microenvironment can be created by a deficiency in factor-inhibiting HIF.

a, Principal component analysis (PCA) of gene expression data from Mutant (Mut), Mutant treated with the Wnt inhibitor IWP2, Corrected (Corr) and Corrected cells treated with Wnt3a (Corr+W) using all 26,830 genes (iGenome UCSC hg38) in our data set at day 16 and b, day 32 (also day 16 included) of neuronal differentiation. c, Mutant cells undergo a global transcriptomic change that we termed “reprogramming” after which they resemble the transcriptomic profile of Corrected cells when a short treatment with an Wnt inhibitor was performed. On the contrary Corrected cells became transcriptionally reprogrammed to resemble the transcriptome of Mutant cells once transiently treated with recombinant Wnt3a protein.

Control of Wnt signalling by KDM5C during development impacts cognition

Shi

Ludwig Oxford’s Yang Shi’s research team identifies KDM5C as a crucial sentinel for neurodevelopment.

Figure 1A and Figure 7 of the full article showing the changes of the MITF interactome upon DNA damage.

Melanoma Genomic Instability increased by DNA damage remodelling the MITF interactome

Goding

The Goding lab shows that Microphthalmia-associated Transcription Factor (MITF) plays a non-transcriptional role in shaping the DNA Damage Response programmes. MITF is phosphorylated on exposure to DNA damaging agents, and interacts with a DNA repair complex, increasing the level of genomic instability within cells which can have an impact on cancer initiation.

Ludwig Oxford celebrates the end of a successful year

Ludwig Oxford meets as a whole to share their science and creativity in talks, posters, writing and art competitions and more for the end of year retreat

Insights made into how Red Hair Colour (RHC) trait variants may increase melanoma risk

Goding

The Goding lab have worked in collaboration with Bill Pavan’s group of the National Human Genome Research Institute, at the National Institutes of Health (NIH), to uncover the transcriptomic profile of MC1R-inhibited melanocytes at single-cell resolution in Pigment Cell & Melanoma Research.

Olly Featherstone receiving a certificate from Professor Gavin Screaton, Head of Division.

Ludwig Oxford DPhil candidate receives MSD Teaching Excellence Award

Goding

Ludwig Oxford’s Olly Featherstone has been awarded an Early Career Excellent Teacher award by the Medical Sciences Division Teaching Excellence Awards.

Ludwig Cancer Research logo

New DPhil studentships in Cancer Science available for 2024 intake

Boccellato Byrne Lu Rittscher Schuster-Böckler Tomkova Van den Eynde White

Ludwig Oxford supervised DPhil studentships in Cancer Science are now being advertised for the 2024 intake

Collaboration announced between Satisfai and University of Oxford to develop AI methods of evaluating Barrett's oesophagus

Rittscher

An agreement between Satisfai Health Inc and the University of Oxford will forward the automated assessment of Barrett’s oesophagus, designed to determine patients with the highest risk of developing oesophageal cancer.

Relative ratio of ChIP peaks with indicated motifs for MITF WT and mutants expressed at 0, 20, and 100 ng doxycycline and comparisons of the peak scores

Acetylation reprograms MITF target selectivity and residence time

Goding

Ludwig Oxford’s Colin Goding and his lab reveal an acetylation-mediated switch that suppresses differentiation and provides an explanation of why a human K206Q MITF mutation is associated with Waardenburg syndrome.

A role for ASPP2 in Hepatitis C infection

Lu

Ludwig Oxford researchers in the Lu lab uncover new insights into the role of ASPP2 in Hepatitis C virus replication and transmission.

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