AI @ Oxford on 27th March 2018 is a unique opportunity for industry to see the state-of-the-art in artificial intelligence and machine learning at Oxford University, and meet Oxford’s AI experts one-to-one. At Ludwig Oxford, Jens Rittscher’s and Xin Lu’s labs are researching the use of machine learning to automate clinical image analysis.
Zinaida Dedeic and colleagues from Xin Lu’s group at Ludwig Oxford have shown how iASPP – a regulator of p53 and p63 – leads to cardiac and skin defects, in a paper published in Cell Death and Differentiation. Mutation of iASPP is known to cause cardiocutaneous syndrome, including cardiac dysfunction and impaired wound healing, but it wasn’t known whether these changes were due to iASPP-mediated regulation in heart and skin cells or via a widespread inflammatory response. Specific deletion of iASPP in either heart or skin cells in this new study supports a cell autonomous role of iASPP in cardiocutaneous disorder.
World Cancer Day on 4th February is dedicated to raising awareness about cancer. The mandate includes the possibility of preventing cancer, advancing and improving access to care, changing perceptions about cancer and building the case for greater global investment in cancer control. Researchers at Ludwig Oxford are trying to understand the epidemiology and potential causes of cancer, as well as the basic science underpinning the unregulated cell growth that is the hallmark of the disease.
Xin Lu, director of the Ludwig Institute of Cancer Research, Oxford Branch, is now an editor of the flagship American Association for Cancer Research (AACR) journal Cancer Research. The journal has a broad scope ranging from research into the genome and metabolism through to translational and population science.
Several Ludwig Institute researchers spoke at the Oxford transcription and chromatin meeting on 7-8th December 2017 at the Oxford Martin School. Xin Lu, Sarah De Val, Colin Goding, David Mole, Chunxiao Song and Skirmantas Kriaucionis all presented research stories from their labs that are related to transcription, the process by which an RNA molecule is produced using DNA as a template. Xin Lu’s lab studies the transcriptional regulator ...
Would you like to join Ludwig Oxford as a graduate student in October 2018? Applications are currently invited for the NDM Prize Studentships - the deadline is 8th January 2018. The wide range of exciting projects at Ludwig are highlighted in our Jobs and Study section. Candidates are judged on the basis of their academic and research potential.
Registration is now open for the 11th European workshop on cell death to be held in Fiuggi, Italy from 6-11th May 2018. The meeting, co-organised by Ludwig researcher Mads Gyrd-Hansen, will focus on cell death, inflammation and cancer, and the participation of younger scientists (PhD students and post-docs) in addition to PIs is encouraged. Apply online by 15th January 2018.
Mutation of a cytosine (C) DNA base to a thymine (T) base is more likely to occur if the C is followed by a guanine (G) and if the C is chemically modified by methylation. This was thought to be mainly due to the spontaneous deamination of methylated C to T. A new study in DNA Repair by Tomkova and colleagues from the labs of Benjamin Schuster-Böckler and Skirmantas Kriaucionis demonstrates that errors introduced during replication may also have a role in the increased mutability of methylated cytosine to thymine.
DPhil student Ruoshi Peng from Mads Gyrd-Hansen’s lab won a prize for a poster she presented at the EMBO Young Investigator’s PhD course in Heidelberg, Germany. In her poster, Ruoshi highlighted a technique she is using to study regulatory proteins modified by chains of small proteins called ubiquitin. Because ubiquitin chains are often very short-lived, these modifications have previously been very difficult to study. However, with this new technique, Ruoshi can investigate the function of ubiquitin chains to understand their role in the regulation of inflammatory cell death.
DPhil student Emma Fenech from John Christianson’s group won a prize for the poster she presented at the EMBO conference on Proteostasis in Ericeira, Portugal. Her research focuses on mapping the molecular interactions of protein machines called ubiquitin ligases that add ubiquitin, a small regulatory protein, to other proteins. One of these ubiquitin ligases is known to regulate signalling in the immune system and she demonstrated that the interactions this ligase makes are important for controlling the immune response.