Margarida Rei
Post-doctoral Fellow
RESEARCH INTERESTS
I am a cancer immunologist with a strong interest in T cell biology. I joined Xin Lu's lab in October 2021 to investigate the role of viral/cancer cross-reactive T cells in oesophageal cancer patients treated with immune checkpoint inhibitors, using single cell sequencing approaches, and TCR screenings.
BACKGROUND
In my previous post-doc with Vincenzo Cerundolo at the MRC Human Immunology Unit in Oxford, I studied tumour-specific T cell responses against ovarian cancer and glioblastoma. During my PhD with Dan Pennington and Bruno Silva-Santos at the Queen Mary University of London and University of Lisbon, I discovered a pro-tumour role of gamma delta T cells in a mouse model of ovarian cancer.
Recent publications
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Semmaphorin 3 A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells.
Journal article
Barnkob MB. et al, (2024), Nat Commun, 15
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HLA-E–restricted SARS-CoV-2–specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation
Journal article
Yang H. et al, (2023), Science Immunology, 8
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PemBla: A Phase 1 study of intravesical pembrolizumab in recurrent non‐muscle‐invasive bladder cancer
Journal article
Woodcock VK. et al, (2023), BJUI Compass, 4, 322 - 330
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Decitabine increases neoantigen and cancer testis antigen expression to enhance T-cell-mediated toxicity against glioblastoma.
Journal article
Ma R. et al, (2022), Neuro-oncology, 24, 2093 - 2106
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Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress.
Journal article
Mensurado S. et al, (2018), PLoS biology, 16