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In an Analysis article published in Nature Reviews Cancer, Gareth Bond and colleagues have shown that that commonly inherited single nucleotide polymorphisms (SNPs) occurring in genes of the p53 pathway affect the incidence of a broad range of cancers, more so than such genetic variants in other pathways. Mutations in p53 pathway genes are commonly found in many types of cancer, and these findings highlight that common inherited genetic

A headshot profile photo of Gareth BondTheir analysis used genome-wide datasets of genetic variation, cancer susceptibility loci derived from hundreds of genome-wide association studies conducted in a broad range of cancers, and expression quantitative trait loci data from many different tissue types. Although p53 pathway genes were enriched in SNPs associated with many cancer types, these genes were not significantly enriched in susceptibility loci for other major disease types.