On 13-14th June 2022, the Oxford Branch of the Ludwig Institute for Cancer Research held their annual retreat to discuss key scientific advances within the Branch and beyond.
Biochemical and structural data reveals a site on ankyrin repeat domain proteins for double hydroxylation by Factor Inhibiting Hypoxia Inducible Factor (FIH).
Clinicians and engineers in Oxford have begun using artificial intelligence alongside endoscopy to get more accurate readings of the pre-cancerous condition Barrett\u2019s oesophagus and so determine patients most at risk of developing cancer.
The drug arsenic trioxide can restore the structure and function of some p53 tumour suppressor mutants, with potential as a future personalised cancer treatment strategy.
An interdisciplinary collaboration generates an advanced model of the human gastrointestinal tract with broad applications for disease research and regenerative medicine.
Ludo Buti and colleagues in Xin Lu\u2019s research group find a path that could reduce colonisation of human stomach cells by the cancer-causing bacteria, Helicobacter pylori.
The sequencing of RNA from individual cells is an increasingly used, powerful method for studying cellular heterogeneity. However, the analysis of single-cell RNA-seq is limited due to the high technical variability between experiments and the inability to perform true technical replicates on the same cell. David Severson and colleagues from the labs of Benjamin Schuster-B\u00f6ckler and Xin Lu have developed a new algorithm, BEARscc, published in Nature Communications, which uses simulation to improve the biological interpretation of single-cell RNA-seq experiments.
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