{ "items": [ "\n\n
\n \n 25 February 2019\n \n
\n\n \n \n \n\n \n \n \nPeople with red hair carry variants of the MC1R gene, which puts them at increased risk of developing melanoma.
\n \n\n\n \n 20 February 2019\n \n
\n\n \n \n \n\n \n \n \n \n \n\n\n \n 15 February 2019\n \n
\n\n \n \n \n\n \n \n \nLudwig Oxford research is helping to combat this devastating disease.
\n \n\n\n \n 28 January 2019\n \n
\n\n \n\n \n\n \n \n \n \n De Val\n \n \n\n \n\n\n
\n \n\n \n \n \nArteries and veins have different types of endothelium but it is unclear how these molecular and functional differences are specified during development.
\n \n\n\n \n 21 January 2019\n \n
\n\n \n \n \n\n \n \n \nThe Journal of Cell Science has interviewed former Ludwig Oxford PhD student Norbert Volkmar as part of their \u201cFirst Person\u201d features.
\n \n\n\n \n 21 December 2018\n \n
\n\n \n \n \n\n \n \n \nCancer metastasis is the primary cause of cancer-related death but it is unclear why cancer cells migrate away from the original tumour site.
\n \n\n\n \n 21 December 2018\n \n
\n\n \n\n \n\n \n \n \n \n Public Engagement\n \n \n\n \n\n\n
\n \n\n \n \n \nStaff and students from NDM, Oncology, IBME and NDORMS raised \u00a3700 for Sobell House in the Christmas raffle organised by our laboratories manager Dr Stan Ng. Thanks to all contributors and corporate donors Eppendorf UK, SLS, NEBiolabs UK and Promega UK!
\n \n\n\n \n 29 November 2018\n \n
\n\n \n\n \n\n \n \n \n \n Public Engagement\n \n \n\n \n\n\n
\n \n\n \n \n \nThree researchers from Ludwig Oxford ran a science workshop for pupils aged 9-11 at St Mary Abbots Primary School. Tammie Bishop, Olivia Lombardi and Virginia Schmid taught the children about DNA biology, mutations and inheritance. The workshop was very successful with one teacher reporting that it was the \u2018talk of the town amongst the children at lunch break afterwards\u2019.
\n \n\n\n \n 13 November 2018\n \n
\n\n \n \n \n\n \n \n \nThree students from Ludwig Oxford have won NDM Graduate Student prizes for 2018.
\n \n\n\n \n 19 October 2018\n \n
\n\n \n\n \n\n \n \n \n \n Lu\n \n \n \n \n Schuster-B\u00f6ckler\n \n \n\n \n\n\n
\n \n\n \n \n \n \n \n\n\n \n 15 October 2018\n \n
\n\n \n\n \n\n \n \n \n \n Public Engagement\n \n \n\n \n\n\n
\n \n\n \n \n \nOn Sunday 14th October 2018, Ludwig Cancer Research teamed up with the Wellcome Trust Centre for Human Genetics to run a stall at the IF Oxford Science and Ideas Festival.
\n \n\n\n \n 13 September 2018\n \n
\n\n \n\n \n\n \n \n \n \n Public Engagement\n \n \n\n \n\n\n
\n \n\n \n \n \nOn Saturday 8th September 2018 12.30-3 pm, the Old Road Campus Research Building (ORCRB), housing Ludwig Cancer Research, the Jenner Institute, the Structural Genomics Consortium (SGC) and the Department of Oncology opened to the public as part of the Oxford Open Doors scheme run by the Oxford Preservation Trust. Each unit had a stand in the main atrium of the building with fun educational activities for all ages.
\n \n\n\n \n 23 July 2018\n \n
\n\n \n \n \n\n \n \n \nA team of six researchers, including Ludwig Oxford\u2019s Sarah De Val and those from Germany and USA, have been awarded a prestigious Fondation Leducq Transatlantic Networks of Excellence Programme grant.
\n \n\n\n \n 23 July 2018\n \n
\n\n \n \n \n\n \n \n \nActivation of the bacteria-sensing NOD receptors triggers inflammatory signalling via Receptor-interacting protein kinase 2 (RIPK2). Since RIPK2 inhibitors targeting the ATP-binding pocket have been shown to block this signalling pathway, it was assumed that RIPK2 kinase activity was important for signal transmission. In this work published recently in EMBO Journal, Hrdinka, Schlicher and colleagues from Mads Gyrd-Hansen\u2019s lab demonstrate that kinase activity is in fact dispensable for NOD signalling and that these RIPK2 inhibitors are instead preventing the binding of the ubiquitin ligase, XIAP, and the subsequent XIAP-mediated ubiquitination of RIPK2 necessary for downstream signalling. This work could have therapeutic implications since NOD signalling is associated with several chronic inflammatory conditions such as Crohn\u2019s disease.
\n \n\n\n \n 11 July 2018\n \n
\n\n \n \n \n\n \n \n \nIt is important for cells to control the balance of nutrients \u2013 including glucose and amino acids \u2013 for proper cell function. A key regulator in this process is the transcription factor, TFEB, which travels to the nucleus upon nutrient limitation to activate the cell\u2019s recycling of unwanted components to restore nutrient levels. Several mechanisms have been described for how nuclear import of TFEB is prevented when nutrient levels are high. In this article published in Nature Communications, Linxin Li, Hans Friedrichsen and colleagues from Prof. Colin Goding\u2019s lab describe an additional control of TFEB cellular localisation. Both amino acid and glucose limitations can alter the phosphorylation status of TFEB in a way that inhibits its nuclear export and thus promotes the activation of cellular recycling. Because deregulation of nutrient levels occurs in many diseases including cancer and neurodegeneration, this work has implications for the development of potential therapeutic interventions.
\n \n\n\n \n 18 June 2018\n \n
\n\n \n \n \n\n \n \n \nThe 7th Annual CRUK Oxford Centre Symposium was held on 15th June 2018 in the Mathematical Institute, Oxford. The day consisted of a varied programme of presentations, ranging from cancer epidemiology to cancer immunotherapy and ended with an inspiring talk from a patient who has benefited from Oxford\u2019s research via an early phase clinical trial. In addition to the talks, the breadth of cancer research at Oxford was showcased by > 60 posters.
\n \n\n\n \n 7 June 2018\n \n
\n\n \n \n \n\n \n \n \nLudwig Oxford\u2019s Sarah De Val was selected to give the prestigious John French lecture at the British Cardiovascular Society Spring Meeting in Manchester. The lecture commemorates the work of John French, a vascular pathologist from the Dunn School of Pathology, Oxford, and is given by an early career scientist of exceptional promise. Sarah talked about her work on blood vessels in development and disease. (Image Copyright Jane Goodall 2018)
\n \n\n\n \n 4 June 2018\n \n
\n\n \n\n \n\n \n \n \n \n Public Engagement\n \n \n\n \n\n\n
\n \n\n \n \n \nA group of Ludwig public engagement volunteers took our newly created family friendly activities to a sunny Headington Festival in Bury Knowle Park on Sunday 3rd June. The Headington Festival is an annual event run by Headington Action and features ~50 stalls from local organisations, plus a programme of live entertainment.
\n \n\n\n \n 30 May 2018\n \n
\n\n \n \n \n\n \n \n \nIn this invited review for Trends in Genetics, Marketa Tomkova and Benjamin Schuster-B\u00f6ckler explore how epigenetic modification of DNA influences mutagenesis. Some modifications such as methylation of DNA on cytosine bases are well known to increase the rate of mutation through a spontaneous chemical change to thymine. DNA modifications also affect the likelihood of DNA mutagenesis by both external factors e.g. UV light or smoking and cell-intrinsic processes e.g. DNA replication. This review discusses what is known to date and some of the outstanding questions in the field.
\n \n\n\n \n 14 May 2018\n \n
\n\n \n\n \n\n \n \n \n \n Public Engagement\n \n \n\n \n\n\n
\n \n\n \n \n \nOn Sunday 13th May 2018, over 20 members of Ludwig Oxford participated in the Town and Gown 10 km run in support of Muscular Dystrophy UK. Carlos Ruiz-Puig was the fastest Ludwig athlete with a time of 43 min. Congratulations to all that took part!
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