Gyrd-Hansen group | Inflammation and cancer
Prof. Mads Gyrd-Hansen
We study molecular mechanisms governing inflammatory signalling and other host-defence processes during innate immune responses. Through this, we aim to understand the molecular events that on one hand protect against pathogens, but that also contribute to chronic inflammation and tumour development, growth and metastasis. A central focus of the lab is to elucidate the role and regulation of ubiquitin modifications in myeloid cells in these processes.
Find out more about research in the Gyrd-Hansen lab.
Our team
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Mads Gyrd-Hansen
Associate Professor
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Kit Lee
Post-doctoral Fellow
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Derek Leske
Post-doctoral Fellow
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Yusuf Topal
Post-doctoral Fellow
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Xuan Wang-Kan
Post-doctoral Fellow
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Oliver Featherstone
DPhil student
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Biao Ma
DPhil student
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Ruoshi Peng
Post-doctoral Fellow
Latest Gyrd-Hansen group news
Selected publications
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Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling
Journal article
Hrdinka M. et al, (2018), The EMBO Journal, 37, e99372 - e99372
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SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling
Journal article
Elliott PR. et al, (2016), Molecular Cell, 63, 990 - 1005
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CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling
Journal article
Hrdinka M. et al, (2016), Cell Reports, 14, 2846 - 2858