We study the part of our immune system that responds immediately to infection. Infection can trigger inflammation, which is an essential part of our defense against invading microbes such as bacteria. But, inflammation can cause cancer if it is not properly controlled. In fact, it is estimated that 1 in 6 cancers worldwide are caused by infections. The aim of our research is to understand how inflammation is controlled by cells and to find ways to prevent disease-causing inflammation.
Our investigations are focused on a control mechanism in our cells that is called 'ubiquitination'. Ubiquitination is a central part of the processes in cells that regulate inflammation.