Contact information
Research groups
Alice Neal
Post-doctoral Fellow
My research focuses on the signalling and transcriptional pathways regulating arteriovenous specification and differentiation in the early embryo.
Although it has been hypothesized that endothelial cells are venous by default while arterial identity is acquired, growing evidence indicates that venous endothelial cell identity is instead dependent upon dynamic gene regulation. My recent research identified multiple vein-specific gene enhancers, and elucidated a BMP-SMAD1/5:SMAD4 regulatory pathway governing early vein specification.
Recent publications
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ETS factors are required but not sufficient for specific patterns of enhancer activity in different endothelial subtypes
Journal article
Neal A. et al, (2021), Developmental Biology, 473, 1 - 14
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Venous identity requires BMP signalling through ALK3.
Journal article
Neal A. et al, (2019), Nature communications, 10
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Differential tissue specific, temporal and spatial expression patterns of the Aggrecan gene is modulated by independent enhancer elements
Journal article
Li IMH. et al, (2018), Scientific Reports, 8
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Endothelial-Specific Cre Mouse Models
Journal article
Payne S. et al, (2018), Arteriosclerosis, Thrombosis, and Vascular Biology, 38, 2550 - 2561
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Correction: SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. Development doi: 10.1242/dev.146241
Journal article
Chiang IK-N. et al, (2017), Development, 144, 3847 - 3848