Chemical modifications of nucleotides have significant effects on cellular processes, notably in a cancerous environment. These modifications are often the result of DNA damage and may serve as mutagenic intermediates. I am interested in understanding the genome-wide role of these modifications and am also developing tools for sequencing single cell epigenetic modifications.
I received a Master’s Degree in Marine Genomics from Madurai Kamaraj University, India. Following this, I joined Madras Veterinary College as a Senior Research Fellow to explore shark immunology. This experience enabled me to evaluate and understand the interplay between chemistry and biological systems. Motivated to study this further, I explored the role of global gene expression profiling on small-molecule mediated cellular re-programming for my doctoral thesis with Professor H. Sugiyama’s Chemical Biology Group in Kyoto University, Japan.
Advancing Development of Synthetic Gene Regulators With the Power of High-Throughput Sequencing in Chemical Biology
Chandran A., (2017)
Identification of Binding Targets of a Pyrrole-Imidazole Polyamide KR12 in the LS180 Colorectal Cancer Genome
Lin J. et al, (2016), PLOS ONE, 11, e0165581 - e0165581
Targeting 24 bp within Telomere Repeat Sequences with Tandem Tetramer Pyrrole–Imidazole Polyamide Probes
Kawamoto Y. et al, (2016), Journal of the American Chemical Society, 138, 14100 - 14107
Genome-Wide Assessment of the Binding Effects of Artificial Transcriptional Activators by High-Throughput Sequencing
Chandran A. et al, (2016), ChemBioChem, 17, 1905 - 1910
Comparative Analysis of DNA-Binding Selectivity of Hairpin and Cyclic Pyrrole-Imidazole Polyamides Based on Next-Generation Sequencing
Kashiwazaki G. et al, (2016), ChemBioChem, 17, 1752 - 1758