I am a researcher based in the Nuffield Department of Medicine (NDM). I am also medical consultant of the Japanese Society of Neurosurgery. My research interests are focused on understanding the physiological and pathological function of oxygen as a signalling molecule through HIF (Hypoxia Inducible Factors) pathway. Together with Professor Chris Pugh, Dr Ben Davies, and Professor Sir Peter Ratcliffe, I have developed novel tetracycline regulated shRNAs targeting the main components of the HIF/PHD (prolyl hydroxylase domain-containing protein) pathway which allow temporally defined bi-directional interventions to be made. My current focus is analysing immune dysregulation using this model. My work forms part of a number of successful collaborative studies with the members of the Nuffield Department of Surgical Sciences Transplantation Research and Immunology Group (Dr Fadi Issa), the Ludwig Institute for Cancer Research (Professor Benoît Van den Eynde), and the Jenner Institute (Professor Helen McShane) in Oxford, and also some groups outside Oxford.
Systemic silencing of Phd2 causes reversible immune regulatory dysfunction
Yamamoto A. et al, (2019), Journal of Clinical Investigation, 129, 3640 - 3656
Hypoxia and HIF pathway in cancer and the placenta
Macklin PS. et al, (2017), Placenta, 56, 8 - 13