My research is focused on elucidating the roles of the ubiquitin system in innate immune signalling, with a particular interest in the links between inflammation and cancer.
Ubiquitin is a post-translational modification which classically was described to serve as a signal for protein degradation; however, of the eight possible types of ubiquitin linkages, most have been assigned non-degradative roles and instead serve scaffolding functions for the recruitment and activation of proteins. Methionine 1 (M1) and lysine 63 (K63)-linked ubiquitin are two possible linkages that have a crucial function in immune signalling events and thus my research focuses on their regulation.
I completed a B.Sc (Hons) Immunology and M.Res Biomedical Science (integrative mammalian biology/systems biology) both at the University of Glasgow. During this time I gained a comprehensive understanding of molecular and cellular immunology and, through my Master’s research, investigated the progression of EBV-induced B cell lymphoma using proteomics and in vivo models. I completed my DPhil at the University of Oxford within the lab of Prof Mads Gyrd-Hansen where I investigated the role of the ubiquitin system within innate immune signalling.
Epstein-Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle.
Deschamps T. et al, (2017), The Journal of general virology, 98, 251 - 265
SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling
Elliott PR. et al, (2016), Molecular Cell, 63, 990 - 1005
CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling
Hrdinka M. et al, (2016), Cell Reports, 14, 2846 - 2858