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Derek Leske

Post-doctoral Fellow

Research interests

My research is focused on elucidating the roles of the ubiquitin system in innate immune signalling, with a particular interest in the links between inflammation and cancer.

Ubiquitin is a post-translational modification which classically was described to serve as a signal for protein degradation; however, of the eight possible types of ubiquitin linkages, most have been assigned non-degradative roles and instead serve scaffolding functions for the recruitment and activation of proteins. Methionine 1 (M1) and lysine 63 (K63)-linked ubiquitin are two possible linkages that have a crucial function in immune signalling events and thus my research focuses on their regulation.

Background

I completed a B.Sc (Hons) Immunology and M.Res Biomedical Science (integrative mammalian biology/systems biology) both at the University of Glasgow. During this time I gained a comprehensive understanding of molecular and cellular immunology and, through my Master’s research, investigated the progression of EBV-induced B cell lymphoma using proteomics and in vivo models. I completed my DPhil at the University of Oxford within the lab of Prof Mads Gyrd-Hansen where I investigated the role of the ubiquitin system within innate immune signalling.

Recent publications

More publications