I completed a Ph.D. in Cancer and Immunology at the University of Lausanne, Switzerland. My work there allowed for the characterisation of an inflammatory response against endogenous DNA, in particular genomic DNA following nuclear envelope disruption.
My current research is based on the development of a novel technology for the characterisation of ubiquitin chains involved in the activation of pro-inflammatory pathways. This new mass spectrometry-based technique allows for the unbiased identification of the exact composition of ubiquitin chains on a target protein and the investigation of deubiquitinase enzyme specificity. This is a very potent approach because it allows the ubiquitin characterisation of virtually every post-translationally modified protein in human cells.
AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity
Di Micco A. et al, (2016), Proceedings of the National Academy of Sciences, 113, E4671 - E4680
An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response
De Gassart A. et al, (2016), Proceedings of the National Academy of Sciences, 113, E117 - E126
Sphingosine Kinase Mediates Resistance to the Synthetic RetinoidN-(4-Hydroxyphenyl)retinamide in Human Ovarian Cancer Cells
Illuzzi G. et al, (2010), Journal of Biological Chemistry, 285, 18594 - 18602
Sphingosine kinase mediates resistance to the synthetic retinoid n-(4-hydroxyphenyl) retinamide in human ovarian cancer cells
Illuzzi G. et al, (2010), FEBS JOURNAL, 277, 142 - 142
Association between Cx43 and beta-Arrestin is Required for cAMP-Dependent Osteoblast Survival Induced by PTH
Plotkin LI. et al, (2008), JOURNAL OF BONE AND MINERAL RESEARCH, 23, S64 - S64