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Gianluca Frera

Post-doctoral Fellow

I completed a Ph.D. in Cancer and Immunology at the University of Lausanne, Switzerland. My work there allowed for the characterisation of an inflammatory response against endogenous DNA, in particular genomic DNA following nuclear envelope disruption.

My current research is based on the development of a novel technology for the characterisation of ubiquitin chains involved in the activation of pro-inflammatory pathways. This new mass spectrometry-based technique allows for the unbiased identification of the exact composition of ubiquitin chains on a target protein and the investigation of deubiquitinase enzyme specificity. This is a very potent approach because it allows the ubiquitin characterisation of virtually every post-translationally modified protein in human cells.

Recent publications

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