I have always been interested in understanding the molecular mechanisms that govern cellular differentiation. One of these mechanisms is gene regulation. I previously studied the regulation of lineage-specific genes by lineage-specific transcription factors. Now I am studying the role of a general epigenetic feature, namely DNA modifications, in transcriptional regulation. I believe our study will provide a deeper understanding of cell differentiation and its mis-regulation, which can lead to tumorigenesis.
I obtained my PhD from Osaka University in Japan. During this time, I developed an interest in B lymphocyte differentiation. In 1999, I moved to Leeds for my postdoc to study gene regulation and chromatin structure. In the second half of my time in Leeds, I combined my main interests in B cell differentiation and epigenetic regulations. Since then, I have been fortunate enough to continue working on and being interested in these themes.
Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion.
Hill L. et al, (2020), Nature
Ikaros prevents autoimmunity by controlling anergy and Toll-like receptor signaling in B cells.
Schwickert TA. et al, (2019), Nature immunology
Precocious expression of Blimp1 in B cells causes autoimmune disease with increased self-reactive plasma cells.
Bönelt P. et al, (2019), EMBO J, 38
Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells
Kreslavsky T. et al, (2017), Nature Immunology, 18, 442 - 455
Differential regulation of sense and antisense promoter activity at the Csf1R locus in B cells by the transcription factor PAX5
Ingram RM. et al, (2011), Experimental Hematology, 39, 730 - 740.e2