I have always been interested in understanding the molecular mechanisms that govern cellular differentiation. One of these mechanisms is gene regulation. I previously studied the regulation of lineage-specific genes by lineage-specific transcription factors. Now I am studying the role of a general epigenetic feature, namely DNA modifications, in transcriptional regulation. I believe our study will provide a deeper understanding of cell differentiation and its mis-regulation, which can lead to tumorigenesis.
I obtained my PhD from Osaka University in Japan. During this time, I developed an interest in B lymphocyte differentiation. In 1999, I moved to Leeds for my postdoc to study gene regulation and chromatin structure. In the second half of my time in Leeds, I combined my main interests in B cell differentiation and epigenetic regulations. Since then, I have been fortunate enough to continue working on and being interested in these themes.
Ikaros prevents autoimmunity by controlling anergy and Toll-like receptor signaling in B cells.
Schwickert TA. et al, (2019), Nature immunology
Precocious expression of Blimp1 in B cells causes autoimmune disease with increased self-reactive plasma cells.
Bönelt P. et al, (2019), EMBO J, 38
Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells
Kreslavsky T. et al, (2017), Nature Immunology, 18, 442 - 455
Differential regulation of sense and antisense promoter activity at the Csf1R locus in B cells by the transcription factor PAX5
Ingram RM. et al, (2011), Experimental Hematology, 39, 730 - 740.e2
The Pu.1 Locus Is Differentially Regulated at the Level of Chromatin Structure and Noncoding Transcription by Alternate Mechanisms at Distinct Developmental Stages of Hematopoiesis
Hoogenkamp M. et al, (2007), Molecular and Cellular Biology, 27, 7425 - 7438