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Marketa Tomkova

Post-doctoral Fellow

Research interests

In my main current research project, I am interested in uncovering the mechanisms of different mutational processes that operate in normal and cancer cells. I have researched the role of DNA replication and DNA modifications in the mutational processes using computational approach and integration of numerous genomic data sets. For instance, we showed that compared to the well-known mutagenicity of 5-methylcytosine, positions with 5-hydroxymethylcytosine are significantly less mutated across different tissues. We also demonstrated a surprisingly widespread footprint of DNA replication in most mutational processes. Finally, our results predict a novel mutagenic process involving replication and cytosine methylation. We are developing an experimental technique capable of detecting rare mutations in single molecules with the aim to validate some of the hypotheses resulting from our computational analyses.

I have also been working on a number of other projects from the area of computational biology/genomics, such as researching the role of DNA modifications in progression of healthy cells to cancer cells. 

Background 

I gained a bachelor and master degree in Computer Science at Charles University in Prague. In my master thesis, I developed the first large-scale computational model of auditory cortex and used it to study how exposure to noise in early development affects properties of the auditory cortex. 

Other interests

I enjoy teaching and communicating science to general audience.

Key publications

Recent publications

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