Many cancer types divide rapidly and require large quantities of DNA precursors. Cells make them through two pathways: de novo synthesis and salvage. I use mass spectrometry to study the relationship between the two pathways and better understand vulnerabilities exploitable for therapy.
I completed my MChem degree in Chemistry at Oxford (2012-2016).
I am part of the ORCRB Social and Green committees.
Capturing the dynamics of genome replication on individual ultra-long nanopore sequence reads
Müller CA. et al, (2019), Nature Methods, 16, 429 - 436
Identification of UHRF2 as a novel DNA interstrand crosslink sensor protein
Motnenko A. et al, PLOS Genetics, 14, e1007643 - e1007643