Paul Miller
Clinical lecturer
Research interests
I am an NIHR clinical lecturer in medical oncology and I investigate how inflammation can initiate and promote cancer. Inflammation is a risk factor for the development of cancer, and an abnormal inflammatory response caused by the cancer is a hallmark of the disease. I use models of cancer development and inflammation to study the key drivers and suppressors of cancer. Understanding how normal inflammatory processes are altered by cancer could enable more effective chemotherapy to be designed to improve outcomes in patients with cancer.
Background
After gaining a degree in cell biology at Durham University I studied graduate medicine at Cambridge University. As an academic foundation doctor at The Christie in Manchester, I developed an interest in brain tumour imaging. I’ve been in Oxford since 2010, initially as an academic clinical fellow, before completing a CRUK clinical research training fellowship in the laboratory of Professor Xin Lu. I started medical oncology training in 2016 and became an NIHR clinical lecturer in 2018.
Other activities
I am a member of the NCRI brain tumour clinical studies group and I’m completing an MSc in Medical Education.
Recent publications
-
p53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation-driven pancreatic cancer
Journal article
Miller P. et al, (2023), Cell Death & Differentiation, 30, 1619 - 1635
-
Regulation of immunological tolerance by the p53-inhibitor iASPP
Journal article
Akama-Garren EH. et al, (2023), Cell Death & Disease, 14
-
Mutant Ras and inflammation-driven skin tumorigenesis is suppressed via a JNK-iASPP-AP1 axis
Journal article
Al Moussawi K. et al, (2022), Cell Reports, 41, 111503 - 111503
-
Ciliogenesis and Hedgehog signalling are supressed downstream of KRas during acinar-ductal metaplasia
Journal article
Bangs FK. et al, (2020), Disease Models & Mechanisms
-
Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells
Journal article
Wang Y. et al, (2019), Autophagy, 15, 886 - 899