I am a DPhil student in the Song lab since October 2016. My work is focused on the development of new epigenetic tools for DNA methylation analysis and their application to cancer clinical samples. I am particularly interested in the characterisation of cancer-specific epigenetic changes in cell-free DNA in order to identify new potential cancer epi-biomarkers that could be used for further development of non-invasive approaches for cancer diagnosis and monitoring.
TAPS: A bisulfite-free, base-resolution and quantitative sequencing method for cytosine modifications
Liu Y. et al, (2019), CANCER RESEARCH, 79
Bisulfite-free direct detection of 5-methylcytosine and 5-hydroxymethylcytosine at base resolution.
Liu Y. et al, (2019), Nature biotechnology, 37, 424 - 429
Bisulfite-free and base-resolution analysis of 5-methylcytidine and 5-hydroxymethylcytidine in RNA with peroxotungstate
Yuan F. et al, (2019), Chemical Communications, 55, 2328 - 2331
Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design
Rahm F. et al, (2018), Journal of Medicinal Chemistry, 61, 2533 - 2551
Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains
Bouché L. et al, (2017), Journal of Medicinal Chemistry, 60, 4002 - 4022