Cells have two ways to source new DNA bases to meet their need, the de novo pathway and the salvage pathway. I am interested in studying how the salvage pathway processes modified nucleotides coming from our diet, knowing that their incorporation into newly synthesised DNA can lead to mutations, the primary cancer aetiology.
I come from France, where I received my Bachelor’s and Master’s degrees in Biology and Chemistry. I then moved to Luxembourg for my PhD and I became interested in the role of epigenetics, especially DNA modifications, in mediating the response to environmental exposures.
Neuronal non-CG methylation is an essential target for MeCP2 function.
Tillotson R. et al, (2021), Mol Cell
Altered DNA modifications in Barrett's oesophagus and oesophageal adenocarcinoma
Kriaucionis S. et al, (2019), CANCER RESEARCH, 79