I joined Professor Mads Gyrd-Hansen’s group as a post-doctoral researcher in 2019. My research focuses on inflammation. Chronic inflammation causes cell death and damage to our tissues. These tissues release DNA-damaging chemicals that can lead to cancer. Therefore, by limiting inflammation we can reduce the risk of developing cancer. One way of reducing inflammation is by targeting ubiquitination, a mechanism of protein modification. The aim of my project is to understand how ubiquitin regulates inflammation and cell death, which can guide the discovery of druggable targets against chronic inflammation.
I did my PhD at the Institute of Microbiology and Infection, University of Birmingham. During my PhD I studied the relationship between antibiotic resistance and virulence in Salmonella Typhimurium. Prior to my PhD, I trained as a Chemist Bacteriologist Parasitologist (undergraduate degree) at the National School of Biological Sciences in Mexico. To obtain my degree, I worked on a research project at the Infectology Department of the Children’s Hospital of Mexico Federico Gomez. This project was on quorum sensing, a bacterial communication system that regulates the expression of virulence factors.
Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB.
Reading E. et al, (2020), Nature communications, 11
Author Correction: Multidrug efflux pumps: structure, function and regulation.
Du D. et al, (2018), Nature reviews. Microbiology, 16
Multidrug efflux pumps: structure, function and regulation.
Du D. et al, (2018), Nature reviews. Microbiology, 16, 523 - 539
Lack of AcrB Efflux Function Confers Loss of Virulence on Salmonella enterica Serovar Typhimurium.
Wang-Kan X. et al, (2017), mBio, 8