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Yilong Lian

Post-doctoral Fellow

Research interests

The laboratory is interested in understanding the role of the Aryl hydrocarbon receptor (AhR) as a sensor of bacteria. AhR senses the presence of bacteria at different stages of infection and regulates the immune responses according to the infection status. I am interested in understanding the dynamics of host-pathogen interactions and the role of AhR signalling in influencing immune responses. In particular, I am focusing on how the host AhR discerns between non-threatening versus potentially threatening infections, and consequently how it regulates immune host defence mechanisms. Concomitantly, I am interested in understanding if and how the AhR is able to modulate bacteria virulence and adaptation strategies during the course of infection.  

Background

I received my PhD from Nanyang Technological University (Singapore) in 2019. My PhD project aimed to elucidate the function of a ribonucleoparticle known as vaults. This was carried out by studying Major vault protein (MVP), the main/structural protein in vaults, using both zebrafish and human cell lines. I discovered that MVP influences host-pathogen interactions between cells and Pseudomonas aeruginosa.