A Synthetic Transcriptional Activator of Genes Associated with the Retina in Human Dermal Fibroblasts
Syed J., Chandran A., Pandian GN., Taniguchi J., Sato S., Hashiya K., Kashiwazaki G., Bando T., Sugiyama H.
AbstractSmall molecules capable of modulating epigenetic signatures can activate the transcription of tissue‐restricted genes in a totally unrelated cell type and have potential use in epigenetic therapy. To provide an example for an initial approach, we report here on one synthetic small‐molecule compound—termed “SAHA–PIP X”—from our library of conjugates. This compound triggered histone acetylation accompanied by the transcription of retinal‐tissue‐related genes in human dermal fibroblasts (HDFs).