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News

Professor Benjamin Schuster-Boeckler elected as a Fellow of the Royal Society of Biology

Ludwig's Ben Schuster-Boeckler has been announced as a Fellow of the Royal Society of Biology

The 2025 branch retreat committee standing with Professor Xin Lu and Professor Chris Pugh.

Ludwig Oxford round up another successful year

Staff and students at Ludwig Oxford celebrate the end of 2024 with Science, Team Building and Prizes

Immunofluorescence characterisation of atrial and ventricular cardiomyocytes. The individual coloured panels show the cTnT, actinin and DAPI stains, then a merged image of each. The atrial cardiomyocytes are shown on the left hand side, whilst the ventricular cardiomyocytes are shown on the right hand side.

Production of biocompatible multifunctional modular iontronics enabled by microscale droplet assembly

The Lu lab collaborates with the École Polytechnique Fédérale de Lausanne and Oxford departments to report the use of surfactant-supported assembly of freestanding microscale hydrogel droplets to construct iontronic modules and biointerfaces.

Suppressing the function of H3K27M mutant histones reduces the drive of incurable paediatric gliomas

The Shi group have leveraged functional genomics in C. elegans to suppress the function of H3K27M mutant histones, which drive 80% of incurable childhood brain tumours diffuse midline gliomas.

decorative image of a fax representing Polymerase epsilon misreading DNA on sheets of paper

Human DNA polymerase ε found to be a source of some of the most prevalent mutations in human cancers and genetic diseases

The Kriaucionis, Schuster-Boeckler and Tomkova groups show that DNA polymerase ε makes errors when replicating methylated CpGs, producing C>T mutations at CpG dinucleotides.

Image showing the two lead authors James McAuliffe and Silvia Panetti, along with Corresponding authors Benoit Van den Eynde and Carol Leung. The right hand side shows a section of the paper's graphical abstract

Cancer vaccination uncovers novel characteristics of a well-known tumour antigen and mediates anti tumour immunity in new settings

The Van den Eynde group identify a new CD8+ T-cell epitope of the MAGE-type P1A tumour antigen presented in a widely-used tumour model, opening new perspectives for mechanistic studies looking at MAGE-type specific anti-tumour immunity.

chemical structure of pseudouridine and a represntation of converting pseudouridine to a cytosine by using BACS

Pseudouridine landscape across the human transcriptome mapped by Ludwig Oxford Researchers

The Song group at Ludwig Oxford publish a technique for mapping the pseudouridine landscape across the human transcriptome in Nature Methods.

Adoptive T cell therapy with PHD2/3-deficient CD8 T cells shows an enhanced tumour response

The Van den Eynde group demonstrate that deletion of PHD2/3 enzymes in CD8 T cells show an enhanced tumour response in various cancer models

The image depicts the graphical abstract of the paper, showing a diagram of the renal system, highlighting the adrenal medulla in the kidneys and the Organ of Zuckerkandl, of which there is also a fluorescence microscopy image next to the diagram. To the right of the diagram, there are graphs showing the oxygen chemosensitivity programmed by HIF-2alpha.

Oxygen chemosensitivity in chromaffin cells programmed by HIF-2α

Members of the Ratcliffe research group (Maria Prange-Barczynska, Holly Jones and Yoichiro Sugimoto) show that activation of HIF-2α is sufficient to confer oxygen chemosensitivity in chromaffin cells.

Silver LEAF award retained by Ludwig Oxford labs

Laboratories at Ludwig Oxford have been re-awarded their silver certificate for sustainability by the Laboratory Efficiency Assessment Framework (LEAF)

Six summer students and post-doctoral researcher Damayanti Chakraborty pose smiling in a line in the lab area. All are wearing white lab coats and either glasses or safety specs.

Ludwig Oxford and IDRM host 6th form students for a taster week of research

Staff and students at Ludwig Oxford and the Institute of Developmental and Regenerative Medicine put on lectures, panel sessions, lab workshops and more for 6th form students with a keen interest in scientific research.

Ludwig Oxford Professor Richard White at the AACR meeting 2024. He appears in a dark grey pullover and blue checked shirt.

Ludwig Oxford's Richard White considers cancer and wandering in the woods

Richard White talks to Oxford Sparks producer Charlotte Bird about cancer, and attempting to find cures in the most unlikely places.

Graphical representation of a protein sequence with N-terminal cysteine residues either being reacted with ADO or NatA to produce differing products with lead to either protein degradation (in the case of the ADO reaction) or a mixture of results from stabilisation to binding to degradation when interacting with NatA.

Protein Stability may be defined by N-terminal cysteine acetylation and oxidation patterns

The Ratcliffe group investigate the relationship between ADO-catalysed oxidation and NatA-catalysed acetylation of a broad range of protein sequences with N-terminal cysteines. This relationship has implications for O2-dependent protein stability and the hypoxic response.

Professor Yang Shi honoured by the Royal Society

Ludwig Oxford Professor Yang Shi has been elected as a Fellow of the Royal Society for his contributions to epigenetics research

Yang Shi elected member of the National Academy of Sciences

We are pleased to announce that Oxford Professor of Epigenetics Yang Shi has been elected as a member of the National Academy of Sciences in the United States.

Image of two Ludwig Oxford Professors. On the left is Colin Goding, wearing a grey jumper and smiling at the camera. On the right is Richard White, also wearing a dark grey-green jumper and looking at the camera.

Ludwig Oxford looks back at Melanoma research in the Branch for Skin Cancer Awareness Month

In May, Skin Cancer Awareness Month, Ludwig Oxford looks at recent research into Melanoma from Professors Richard White and Colin Goding

A group photo showing, from left to right: Benoit Van den Eynde, Jedd Wolchok, Hannah Fuchs, Xin Lu, Benjamin Schuster-Boeckler, Nickolas Papadopoulos and Pat Morin.

Ludwig Oxford at 2024 AACR

Ludwig Oxford staff and students alike share their research in San Diego at the 2024 AACR Annual Meeting

Photo of leadership fellow Francesco Boccellato with dark hair and brown eyes, turning to face the camera and wearing a dark blue jacket

Francesco Boccellato receives esteemed Lee Placito Research Fellowship

Ludwig Oxford’s Francesco Boccellato has received the prestigious Lee Placito Research Fellowship in Gastrointestinal Cancer.

Marketa Tomkova (centre) receiving her award with the director of Czekpats in Science Matouš Glance and board member Markéta Icha Kubánková.

Ludwig Oxford’s Marketa Tomkova is the first recipient of the Czexpats in Science Award

Ludwig Oxford’s Marketa Tomkova has been awarded the very first Czexpats in Science Award for her success in the field of genomics and DNA sequencing

Early events following von Hippel Lindau inactivation shape the trajectory of cancer initiation in the kidney

Work from the Ratcliffe research group demonstrates the early events defining the cell-type specificity of oncogenesis, providing a focus for mechanistic understanding and therapeutic targeting.

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