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Ludwig Oxford welcomes Professor Helen Byrne

Byrne

This new joint appointment between the Ludwig Oxford Branch and the University of Oxford’s Mathematical Institute will strengthen the mathematical and computational modelling capabilities at Ludwig Oxford.

Applications open for Ludwig-funded DPhil in Clinical Medicine

Byrne Constantinescu Kriaucionis Lu Schuster-Böckler Shi Song

Ludwig Oxford is currently recruiting exceptional students for funded four-year Ludwig DPhil studentships commencing in October 2022. Apply by 24th June 2022.

Unexpected hydroxylation

Lu

Biochemical and structural data reveals a site on ankyrin repeat domain proteins for double hydroxylation by Factor Inhibiting Hypoxia Inducible Factor (FIH).

Vacancy - Senior Postdoctoral Researcher

Jobs Schuster-Böckler

Grade 8: Salary in range £42,149 - £50,296 per annum. Apply by June 7, 2022.

Vacancy: Research Integrity Manager

Jobs

Grade 7: £33,309 - £40,927 with a discretionary range to £44,706 per annum. Apply by 3rd June 2022.

CRUK Oxford Centre Development Fund awarded to Dr Romuald Binet

Goding

Ludwig Oxford’s Dr Romuald Binet will investigate tissue-specific regulation of the DNA damage response in melanoma.

Funding to study stomach cancer development

Boccellato

Dr Francesco Boccellato receives a John Fell Fund award to investigate how the stomach lining changes shape during the transition from healthy tissue to cancer.

Ludwig Oxford at AACR 2022

Lu Ratcliffe

Several Ludwig Oxford researchers present at the American Association for Cancer Research (AACR) Annual Meeting.

Automated assessment of pathology image quality

Rittscher

The new Oxford-developed artificial intelligence tool PathProfiler automates the quality control of large retrospective pathology image datasets to increase their usability in downstream research.

Ludwig Oxford’s Professor Yang Shi named as AACR Fellow

Shi

Professor Yang Shi has been elected Fellow of the Academy of the American Association for Cancer Research (AACR), class of 2022.

First major UK prospective study for liver cancer underway

Barnes

The Pearl clinical study will recruit 3000 patients with high-risk conditions for liver cancer with the aim of detecting liver cancer earlier as part of the Cancer Research UK-funded DeLIVER programme led by Ludwig adjunct Professor Ellie Barnes.

Understanding the role of m6A RNA modification in transcription

Shi

Research by Professor Yang Shi and colleagues suggests that METTL3-mediated RNA methylation promotes productive transcription.

London Marathon to fund De Val Lab research as one of eight handpicked BHF projects

De Val

A project aimed at tackling heart failure led by Associate Professor Sarah De Val is to be funded by the 2022 TCS London Marathon with the British Heart Foundation as its Charity of the Year.

First patient dosed in phase I/IIa trial of lung cancer immunotherapy vaccine

Van den Eynde

A novel immunotherapeutic called VTP-600, based on Ludwig Oxford’s Benoit Van den Eynde’s preclinical research, is being tested in patients for the first time.

Two new Ludwig Oxford professors

Constantinescu Shi

Congratulations to Yang Shi and Stefan Constantinescu who have been successful in the 2021 University of Oxford recognition exercise.

Increasing the durability of immunotherapy

Shi

Professor Yang Shi’s laboratory uncovers an important role for the chromatin regulator LSD1 in T cell exhaustion and demonstrates that LSD1 inhibition in mice increases the durability of responses to immune checkpoint blockade therapy.

MP Anneliese Dodds tours Oxford cancer research

Rittscher Song

Anneliese Dodds, MP for Oxford East & Chair of the Labour Party, visited the University of Oxford to learn more about the impactful cancer research happening across departments, including Ludwig Oxford.

New view of a transcriptional regulator driving melanoma proliferation

Goding

A study from Professor Colin Goding’s group finds an unexpected mechanism controlling growth vs senescence in cancer.

The point of no return: chromatin enforces cell fate decisions

Shi

Interactions between transcription factors and the chromatin environment provide barriers controlling cell differentiation, according to research by Professor Yang Shi and colleagues.

Developmental origins of inherited cancers bearing mutations in the oxygen-sensing pathway

Ratcliffe

Dr Tammie Bishop’s and Professor Sir Peter Ratcliffe’s groups shed light on the developmental origins of inherited cancers with mutations in the HIF pathway.

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