Constantinescu group | Signalling, chromatin, haematopoiesis and cancer
Professor Stefan constantinescu
The Constantinescu group at Ludwig Oxford studies the link between signalling, epigenetic regulators, chromatin dynamics and differentiation in myeloid blood cancers. Overall, our objectives are to determine:
- The effects induced by drivers of myeloproliferative neoplasms (MPNs) on epigenetic regulators via post-translational modifications of effectors and transcriptional changes;
- The impact of mutations in epigenetic regulators on chromatin states that allow oncogenesis in the myeloid blood lineage;
- The molecular basis of progression of chronic myeloproliferative neoplasms and myelodysplasia into secondary acute myeloid leukaemia.