Schuster-Böckler group | Computational genomics
Cancer is a disease driven by mutations. Mutagens, such as tobacco smoke or UV light, can influence the frequency and distribution of mutations in the genome. Beyond the few well-known environmental mutagens, cancer genomics projects have revealed that every cancer type, and often even certain sub-types, are characterised by unique patterns in the type and frequency of mutations in their genomes.
Our group is interested in integrating diverse data sets to uncover new mechanisms that influence the mutational process. In particular, we are studying the effect of epigenetic changes, such as chromatin structure or DNA modifications, on the frequency and distribution of mutations in cancer.