Kriaucionis group | Epigenetic mechanisms
Our research programme aims to elucidate the molecular function of DNA modifications in normal cells and cancer. We employ biochemistry and in vivo approaches to investigate roles of DNA modifications in transcription, heritability, mutability and nuclear organisation. Together with advancing knowledge of the basic biology of DNA, we delineate defects in cancer and aim to target them for therapy.
We commonly use:
- Classical enzyme biochemistry;
- Genome wide DNA modification mapping, protein mapping and gene expression analysis using massively parallel sequencing;
- Genome editing in cell lines and in vivo;
- Modified nucleotide and nucleoside detection and quantitation.