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Distal regulatory elements control gene expression during differentiation. In this issue of Molecular Cell, Barnett et al. (2020) develop a new technology, called ATAC-Me, and discover that removal of DNA methylation is not a pre-requisite for the creation of accessible chromatin at active gene regulatory elements during cellular differentiation.

Original publication

DOI

10.1016/j.molcel.2020.02.026

Type

Journal article

Journal

Molecular cell

Publication Date

03/2020

Volume

77

Pages

1159 - 1161

Addresses

Ludwig Cancer Research Oxford, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK. Electronic address: skirmantas.kriaucionis@ludwig.ox.ac.uk.

Keywords

Chromatin, Cell Differentiation, DNA Methylation, Regulatory Sequences, Nucleic Acid