A Graph Based Neural Network Approach to Immune Profiling of Multiplexed Tissue Samples.

Martin NG., Malacrino S., Wojciechowska M., Campo L., Jones H., Wedge DC., Holmes C., Sirinukunwattana K., Sailem H., Verrill C., Rittscher J.

Multiplexed immunofluorescence provides an un-precedented opportunity for studying specific cell-to-cell and cell microenvironment interactions. We employ graph neural networks to combine features obtained from tissue morphology with measurements of protein expression to profile the tumour microenvironment associated with different tumour stages. Our framework presents a new approach to analysing and processing these complex multi-dimensional datasets that overcomes some of the key challenges in analysing these data and opens up the opportunity to abstract biologically meaningful interactions.

DOI

10.1109/embc48229.2022.9871251

Type

Journal article

Journal

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Publication Date

07/2022

Volume

2022

Pages

3063 - 3067

Keywords

Staining and Labeling, Cell Communication, Tumor Microenvironment, Neural Networks, Computer

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