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Key Points Germline JAK2V617I mutation as a sole genetic event does not suppress hematopoietic stem cells. JAK2V617I induces weaker constitutive activation than JAK2V617F but considerable cytokine hyperresponsiveness.

Original publication

DOI

10.1182/blood-2012-05-430926

Type

Journal article

Journal

Blood

Publisher

American Society of Hematology

Publication Date

16/05/2013

Volume

121

Pages

4156 - 4165