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Targeted cancer nanotherapeutics offers numerous opportunities for the selective uptake of toxic chemotherapies within tumors and cancer cells. The unique properties of nanoparticles, such as their small size, large surface-to-volume ratios, and the ability to achieve multivalency of targeting ligands on their surface, provide superior advantages for nanoparticle-based drug delivery to a variety of cancers. This review highlights various key concepts in the design of targeted nanotherapeutics for cancer therapy, and discusses physicochemical parameters affecting nanoparticle targeting, along with recent developments for cancer-targeted nanomedicines.

Original publication

DOI

10.1007/978-1-4939-6646-2_2

Type

Journal article

Journal

Methods Mol Biol

Publication Date

2017

Volume

1530

Pages

13 - 37

Keywords

Antibodies, Cancer, Drug delivery, EPR, Ligands, Multivalency, Nanomedicine, Nanoparticles, Nanotherapeutics, Oncology, Targeting, Translation, Antineoplastic Agents, Drug Carriers, Drug Delivery Systems, Humans, Molecular Targeted Therapy, Nanomedicine, Nanoparticles, Neoplasms, Surface Properties, Tumor Microenvironment