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Researchers from Dr Tammie Bishop’s and Prof Sir Peter Ratcliffe’s laboratories show that an anti-cancer HIF inhibitor impairs the normal ventilatory response to low oxygen.

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Oxygen chemosensitivity in chromaffin cells programmed by HIF-2α

Members of the Ratcliffe research group (Maria Prange-Barczynska, Holly Jones and Yoichiro Sugimoto) show that activation of HIF-2α is sufficient to confer oxygen chemosensitivity in chromaffin cells.

Protein Stability may be defined by N-terminal cysteine acetylation and oxidation patterns