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Activation of hypoxia inducible factors (HIFs) by either hypoxia or drug treatment inhibits SARS-CoV-2 entry and replication in lung epithelial cells, raising the potential of using clinically licensed HIF activators to prevent and/or treat COVID-19.

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Oxygen chemosensitivity in chromaffin cells programmed by HIF-2α

Members of the Ratcliffe research group (Maria Prange-Barczynska, Holly Jones and Yoichiro Sugimoto) show that activation of HIF-2α is sufficient to confer oxygen chemosensitivity in chromaffin cells.

Protein Stability may be defined by N-terminal cysteine acetylation and oxidation patterns