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Search results

Found 18 matches for

Colin Goding’s lab study the expression of ABCB5, with implications for drug resistance

Melanoma progression driven in part by fatty acid uptake

The Goding lab working in collaboration with the University Rey Juan Carlos show that fatty acid uptake activates an AXL-CAV1-β-catenin axis to drive melanoma invasiveness.

Colin Goding presented with Lifetime Achievement Award from Society for Melanoma Research

Professor Colin Goding has been named as the 2024 Lifetime Achievement Award by the Society for Melanoma Research

Ludwig Oxford looks back at Melanoma research in the Branch for Skin Cancer Awareness Month

In May, Skin Cancer Awareness Month, Ludwig Oxford looks at recent research into Melanoma from Professors Richard White and Colin Goding

Melanoma Genomic Instability increased by DNA damage remodelling the MITF interactome

The Goding lab shows that Microphthalmia-associated Transcription Factor (MITF) plays a non-transcriptional role in shaping the DNA Damage Response programmes. MITF is phosphorylated on exposure to DNA damaging agents, and interacts with a DNA repair complex, increasing the level of genomic instability within cells which can have an impact on cancer initiation.

Insights made into how Red Hair Colour (RHC) trait variants may increase melanoma risk

The Goding lab have worked in collaboration with Bill Pavan’s group of the National Human Genome Research Institute, at the National Institutes of Health (NIH), to uncover the transcriptomic profile of MC1R-inhibited melanocytes at single-cell resolution in Pigment Cell & Melanoma Research.

Ludwig Oxford DPhil candidate receives MSD Teaching Excellence Award

Ludwig Oxford’s Olly Featherstone has been awarded an Early Career Excellent Teacher award by the Medical Sciences Division Teaching Excellence Awards.

Acetylation reprograms MITF target selectivity and residence time

Ludwig Oxford’s Colin Goding and his lab reveal an acetylation-mediated switch that suppresses differentiation and provides an explanation of why a human K206Q MITF mutation is associated with Waardenburg syndrome.

Delving into MITF’s regulatory network in melanoma

Research from Ludwig Oxford’s Colin Goding and Department of Oncology’s Francesca Buffa uncovers new genes regulated by MITF in the context of the melanoma tumour microenvironment.

Ludwig Oxford retreat 2022 – a recap

On 13-14th June 2022, the Oxford Branch of the Ludwig Institute for Cancer Research held their annual retreat to discuss key scientific advances within the Branch and beyond.

CRUK Oxford Centre Development Fund awarded to Dr Romuald Binet

Ludwig Oxford’s Dr Romuald Binet will investigate tissue-specific regulation of the DNA damage response in melanoma.

New view of a transcriptional regulator driving melanoma proliferation

A study from Professor Colin Goding’s group finds an unexpected mechanism controlling growth vs senescence in cancer.

Investigating drug resistance in melanoma

Ludwig Oxford’s Professor Colin Goding and Sao Paulo’s Professor Silvya Stuchi Maria-Engler show that TOP1 is involved in melanoma progression and adaptive resistance to treatment.

Understanding the role of BRN2 in melanoma

A study from Professor Colin Goding’s group gives insight into the function of the BRN2 transcription factor in promoting melanoma initiation and metastasis.

Reporter assay to identify dormant cells

Professor Colin Goding’s lab collaborate with colleagues in Germany to develop a new method to measure stem cell dormancy.

Insights into the two faces of AMPK, a key nutrient sensor

Professor Colin Goding and colleagues reveal that a distinct metabolic environment in colon cancer cells allows AMPK to be activated by glucose to drive cancer proliferation, with implications for AMPK-targeting cancer drugs.

Debunking assumptions

Researchers from Colin Goding’s lab demonstrate that weakening a transcription factor’s DNA binding affinity in vitro paradoxically increases its function in vivo.

Fatty acid metabolism in melanoma

Colin Goding’s lab investigates how MITF regulates fatty acid metabolism in melanoma to control cell state-switching, an important contributor to cancer metastasis and therapy resistance.

Questioning melanoma disease state markers

Colin Goding’s lab study the expression of ABCB5, with implications for drug resistance

Similar stories

Melanoma progression driven in part by fatty acid uptake

The Goding lab working in collaboration with the University Rey Juan Carlos show that fatty acid uptake activates an AXL-CAV1-β-catenin axis to drive melanoma invasiveness.

Colin Goding presented with Lifetime Achievement Award from Society for Melanoma Research