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Ludwig Oxford’s Professor Sir Peter Ratcliffe receives the Nobel Prize in physiology or medicine at an awards ceremony in Stockholm.

A photo from the Nobel Prize talks 2019 showing the three nominees for Medicine or Physiology on the stage.

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HIFs inhibit SARS-CoV-2 infection of lung epithelial cells

Activation of hypoxia inducible factors (HIFs) by either hypoxia or drug treatment inhibits SARS-CoV-2 entry and replication in lung epithelial cells, raising the potential of using clinically licensed HIF activators to prevent and/or treat COVID-19.

Anti-cancer HIF-2 inhibition affects the hypoxic ventilatory response

Researchers from Dr Tammie Bishop’s and Prof Sir Peter Ratcliffe’s laboratories show that an anti-cancer HIF inhibitor impairs the normal ventilatory response to low oxygen.