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Peter Ratcliffe shares the prize with William Kaelin of the Dana-Farber Cancer Institute and Gregg Semenza of John Hopkins University for their research on cellular responses to hypoxia.

FRS Peter Ratcliffe - Professor of Clinical MedicineThe 2019 Nobel Prize for physiology or medicine was announced on Monday 7th October. This year’s award is for the discovery of how cells sense and adapt to varying oxygen levels, a cellular process with underlying implications in multiple diseases including cancer.

Sir Peter is a full member of the Ludwig Institute for Cancer Research Oxford Branch, Director of the Target Discovery Institute in Oxford and Clinical Research Director at the Francis Crick Institute in London. You can read more about Peter Ratcliffe's career and research in the Ludwig Research Highlights report here.

 

Please see the Oxford University press release or contact the Oxford News Office (+44 1865 280528 or news.office@admin.ox.ac.uk) for more information.

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The Ratcliffe group investigate the relationship between ADO-catalysed oxidation and NatA-catalysed acetylation of a broad range of protein sequences with N-terminal cysteines. This relationship has implications for O2-dependent protein stability and the hypoxic response.