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Zinaida Dedeic and colleagues from Xin Lu’s group at Ludwig Oxford have shown how iASPP - a regulator of p53 and p63 - leads to cardiac and skin defects, in a paper published in Cell Death and Differentiation. Mutation of iASPP is known to cause cardiocutaneous syndrome, including cardiac dysfunction and impaired wound healing, but it wasn’t known whether these changes were due to iASPP-mediated regulation in heart and skin cells or via a widespread inflammatory response. Specific deletion of iASPP in either heart or skin cells in this new study supports a cell autonomous role of iASPP in cardiocutaneous disorder.