The endoplasmic reticulum (ER) quality control machinery continuously assesses, differentiates and determines the fate of newly synthesized proteins. The decision is made to export properly folded proteins, or to attempt to repair/refold misfolded proteins or degrade them if they are irreparable. Donem’s work will investigate the interaction networks, mechanisms and regulation of ER-resident ubiquitin ligases, which are essential for clearing misfolded proteins and maintaining ER function. ER quality control is implicated in cancer and this work will enhance understanding of how the ER operates under normal and stress conditions.
Donem Avci awarded EMBO Fellowship
22 July 2015
Donem Avci, a postdoctoral researcher in John Christianson’s group in Ludwig Oxford has been awarded an EMBO Long-term Fellowship for her work on the endoplasmic reticulum quality control machinery.