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DNA methylation has been well studied and is known to influence development and disease. In contrast, the dearth of suitable RNA methylation sequencing methods has meant that much less is known about these modifications.

In this paper published in Chemical Communications, Ludwig Oxford’s Fang Yuan and Ying Bi from Chunxiao Song’s group develop a base-resolution sequencing method for 5-methylcytidine and 5-hydroxymethylcytidine based on a peroxotungstate oxidation reaction. This method will enable important further characterisation of these modifications.