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Mads Gyrd-Hansen’s group have published a new paper in Cell Reports that provides new molecular insights into the way a specific type of protein modification, called ubiquitin, is regulated.

Mads Gyrd-Hansen and another researcher studying a Western blot X-ray film in the labUbiquitin is assembled into polymeric chains attached to proteins in a specific manner as a crucial part of signalling in the innate immune system, as well as other processes. This recent study improves our knowledge of how inflammatory signalling is regulated by the precise balance of activity of proteins that add and remove ubiquitin linkages. Unsolved inflammation is an important contributory factor in cancer and other diseases.