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<jats:p>Skin cancer is the most common type of cancer worldwide. Ozone depletion and climate changes might cause a further increase in the incidence rate in the future. Although the early detection of skin cancer enables it to be treated successfully, some tumours can evolve and become more aggressive, especially in the case of melanoma. Therefore, good diagnostic and prognostic markers are needed to ensure correct detection and treatment. Transcription factor p63, a member of the p53 family of proteins, plays an essential role in the development of stratified epithelia such as skin. In this paper, we conduct a comprehensive review of p63 expression in different types of skin cancer and discuss its possible use in the diagnosis and prognosis of cutaneous tumours.</jats:p>

Original publication

DOI

10.3390/ijms20225781

Type

Journal article

Journal

International Journal of Molecular Sciences

Publisher

MDPI AG

Publication Date

17/11/2019

Volume

20

Pages

5781 - 5781