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Pseudomonas aeruginosa rapidly adapts to altered conditions by quorum sensing (QS), a communication system that it uses to collectively modify its behavior through the production, release, and detection of signaling molecules. QS molecules can also be sensed by hosts, although the respective receptors and signaling pathways are poorly understood. We describe a pattern of regulation in the host by the aryl hydrocarbon receptor (AhR) that is critically dependent on qualitative and quantitative sensing of P. aeruginosa quorum. QS molecules bind to AhR and distinctly modulate its activity. This is mirrored upon infection with P. aeruginosa collected from diverse growth stages and with QS mutants. We propose that by spying on bacterial quorum, AhR acts as a major sensor of infection dynamics, capable of orchestrating host defense according to the status quo of infection.

Original publication

DOI

10.1126/science.aaw1629

Type

Journal article

Journal

Science (New York, N.Y.)

Publication Date

12/2019

Volume

366

Addresses

Department of Immunology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany. pedro.mouraalves@ludwig.ox.ac.uk kaufmann@mpiib-berlin.mpg.de.