Transglutaminase 3 Reduces the Severity of Psoriasis in Imiquimod-Treated Mouse Skin
Piro M., Ventura A., Smirnov A., Saggini A., Lena A., Mauriello A., Bianchi L., Melino G., Candi E.
Four transglutaminase (TG) isoforms have been detected in epidermal keratinocytes: TG1, TG2, TG3, and TG5. Except for TG1 and TG3, their contribution to keratinocyte development and structure remains undefined. In this paper, we focused on the roles of TG2 and TG3 in imiquimod-induced psoriasis in mouse skin. We evaluated the severity of psoriasis markers in the skin of imiquimod-treated TG3 null and TG2 null mice. Our results showed that compromised TG3KO mouse skin was more responsive than WT or TG2KO mouse skin to the action of the pro-inflammatory drug imiquimod.