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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Four transglutaminase (TG) isoforms have been detected in epidermal keratinocytes: TG1, TG2, TG3, and TG5. Except for TG1 and TG3, their contribution to keratinocyte development and structure remains undefined. In this paper, we focused on the roles of TG2 and TG3 in imiquimod-induced psoriasis in mouse skin. We evaluated the severity of psoriasis markers in the skin of imiquimod‐treated TG3 null and TG2 null mice. Our results showed that compromised TG3KO mouse skin was more responsive than WT or TG2KO mouse skin to the action of the proinflammatory drug imiquimod.

Original publication

DOI

10.3390/ijms21051566

Type

Journal article

Journal

International Journal of Molecular Sciences

Publication Date

01/03/2020

Volume

21