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BackgroundRisk assessment is relevant to predict postoperative outcomes in patients with gastro-oesophageal cancer. This cohort study aimed to assess body composition changes during neoadjuvant chemotherapy and investigate their association with postoperative complications.MethodsConsecutive patients with gastro-oesophageal cancer undergoing neoadjuvant chemotherapy and surgery with curative intent between 2016 and 2019 were identified from a specific database and included in the study. CT images before and after neoadjuvant chemotherapy were used to assess the skeletal muscle index, sarcopenia, and subcutaneous and visceral fat index.ResultsIn a cohort of 199 patients, the mean skeletal muscle index decreased during neoadjuvant therapy (from 51·187 to 49·19 cm2 /m2 ; P ConclusionSkeletal muscle index decreased during neoadjuvant therapy but was not associated with postoperative complications.

Original publication




Journal article


BJS open

Publication Date





847 - 854


Departments of Surgery, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands.


Muscle, Skeletal, Esophagogastric Junction, Humans, Esophageal Neoplasms, Stomach Neoplasms, Postoperative Complications, Tomography, X-Ray Computed, Treatment Outcome, Neoadjuvant Therapy, Esophagectomy, Regression Analysis, Retrospective Studies, Body Composition, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male, Sarcopenia, United Kingdom