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Antigenic peptides presented by major histocompatibility complex (MHC) class II molecules are generally derived from exogenous proteins acquired by antigen presenting cells. However, in some circumstances, MHC class II molecules can present intracellular proteins expressed within the antigen-presenting cells. There are several described pathways by which endogenous antigens are degraded and gain access to MHC class II molecules. These include autophagy and other non-autophagic pathways; the latter category includes the MHC class I-like pathways, heat shock protein 90-mediated pathways, and internalization from the plasma membrane. This review will summarize and discuss the non-autophagic pathways.

Original publication

DOI

10.3389/fimmu.2015.00464

Type

Journal article

Journal

Frontiers in immunology

Publication Date

01/2015

Volume

6

Addresses

Department of Haematology, University College London Cancer Institute, University College London , London , UK.