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Modelling adult diseases to understand their aetiology and progression, and to develop new therapies, is a major challenge for medical biology. We are excited by new efforts in the zebrafish community to develop models of adult diseases that range from cancer to heart, infectious and age-related diseases, and those that relate to toxicology and complex social behaviours. Here, we discuss some of the advances in the field of zebrafish models of adult disease, and where we see opportunities and challenges ahead.

Original publication




Journal article


Disease models & mechanisms

Publication Date





Ludwig Cancer Institute, Nuffield Department of Medicine, Old Road Campus Research Building, University of Oxford, Roosevelt Drive, Oxford OX3 7DQ, UK.


Heart, Animals, Zebrafish, Humans, Neoplasms, Disease Models, Animal, Social Behavior, Adult