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<jats:title>SUMMARY</jats:title><jats:p>A trispanning orphan receptor (TOR) has been described in <jats:italic>Schistosoma haematobium</jats:italic> and <jats:italic>S. mansoni</jats:italic>. Here we report the complete molecular organization of the <jats:italic>S. mansoni</jats:italic> TOR gene, also known as SmCRIT (complement C2 receptor inhibitor trispanning). The SmTOR gene consists of 4 exons and 3 introns as shown by cloning the single exons from <jats:italic>S. mansoni</jats:italic> genomic DNA and the corresponding cDNA from the larval stage (cercaria) and the adult worm. The SmTOR ORF consists of 1260 bp and is longer than previously reported, with a fourth trans-membrane domain (proposed new name: Tetraspanning Orphan Receptor) and with, however, an unchanged C2-binding domain on the extracellular domain 1 (ed1). This domain differs in <jats:italic>S. japonicum</jats:italic>. A protein at the approximate expected molecular weight (55 kDa) was detected in adult worm extracts with polyclonal and monoclonal antibodies, and was found to be expressed on the tegumental surface of cercariae.</jats:p>

Original publication

DOI

10.1017/s0031182009005757

Type

Journal article

Journal

Parasitology

Publisher

Cambridge University Press (CUP)

Publication Date

04/2009

Volume

136

Pages

487 - 498