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Publications

Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6

Cockman ME. et al, (2022), Proceedings of the National Academy of Sciences, 119

Factor inhibiting HIF can catalyze two asparaginyl hydroxylations in VNVN motifs of ankyrin fold proteins.

Leissing TM. et al, (2022), The Journal of biological chemistry, 298

Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation.

Frise MC. et al, (2022), Scientific reports, 12

Harveian Oration 2020: Elucidation of molecular oxygen sensing mechanisms in human cells: implications for medicine.

Ratcliffe PJ., (2022), Clinical medicine (London, England), 22, 23 - 33

Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma.

Eckardt L. et al, (2021), Endocrine-related cancer, 28, 757 - 772

The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes.

Ortmann BM. et al, (2021), Nature genetics, 53, 1022 - 1035

Precisely Tuned Inhibition of HIF Prolyl Hydroxylases Is Key for Cardioprotection After Ischemia

Jatho A. et al, (2021), Circulation Research, 128, 1208 - 1210

Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells

Wing PAC. et al, (2021), Cell Reports, 35, 109020 - 109020

Endothelial Oxygen Sensing in Alveolar Maintenance.

Hodson E. and Ratcliffe P., (2020), American journal of respiratory and critical care medicine, 202, 917 - 919

Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control

Cheng X. et al, (2020), Journal of Clinical Investigation, 130, 2237 - 2251

Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)-mediated induction of the long noncoding RNA NICI.

Lauer V. et al, (2020), The Journal of biological chemistry, 295, 4065 - 4078

Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)-mediated induction of the long noncoding RNA NICI.

Lauer V. et al, (2020), The Journal of biological chemistry, 295, 4065 - 4078

Structure‐Activity Relationship and Crystallographic Studies on 4‐Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors

Holt‐Martyn JP. et al, (2020), ChemMedChem, 15, 270 - 273

Genetic basis of oxygen sensing in the carotid body: HIF2α and an isoform switch in cytochrome c oxidase subunit 4

Bishop T. and Ratcliffe PJ., (2020), Science Signaling, 13

Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer

Schmid V. et al, (2019), Scientific Reports, 9

Mechanisms of hypoxia signalling: new implications for nephrology

Schödel J. and Ratcliffe PJ., (2019), Nature Reviews Nephrology, 15, 641 - 659

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates

Cockman ME. et al, (2019), eLife, 8

Systemic silencing of Phd2 causes reversible immune regulatory dysfunction

Yamamoto A. et al, (2019), Journal of Clinical Investigation, 129, 3640 - 3656

Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants

Masson N. et al, (2019), Science, 365, 65 - 69

Inherent DNA ‐binding specificities of the HIF ‐1α and HIF ‐2α transcription factors in chromatin

Smythies JA. et al, (2019), EMBO reports, 20

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