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Publications

Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor

England KS. et al, (2014), Med. Chem. Commun., 5, 1879 - 1886

Ribosomal oxygenases are structurally conserved from prokaryotes to humans

Chowdhury R. et al, (2014), Nature, 510, 422 - 426

5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation

Hopkinson RJ. et al, (2013), Chemical Science, 4, 3110 - 3110

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

Rose NR. et al, (2012), Journal of Medicinal Chemistry, 55, 6639 - 6643

Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases

Woon ECY. et al, (2012), Angewandte Chemie International Edition, 51, 1631 - 1634

Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family

Hillringhaus L. et al, (2011), Journal of Biological Chemistry, 286, 41616 - 41625

A Selective Inhibitor and Probe of the Cellular Functions of Jumonji C Domain-Containing Histone Demethylases

Luo X. et al, (2011), Journal of the American Chemical Society, 133, 9451 - 9456

Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase

Zhang Z. et al, (2011), Biochemical and Biophysical Research Communications, 408, 553 - 558

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

King ONF. et al, (2010), PLoS ONE, 5, e15535 - e15535

Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches

Rose NR. et al, (2010), Journal of Medicinal Chemistry, 53, 1810 - 1818

A miniaturized screen for inhibitors of Jumonji histone demethylases

Sakurai M. et al, (2010), Mol. BioSyst., 6, 357 - 364

Dynamic protein methylation in chromatin biology

Ng SS. et al, (2009), Cellular and Molecular Life Sciences, 66, 407 - 422

Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases⊥

Rose NR. et al, (2008), Journal of Medicinal Chemistry, 51, 7053 - 7056

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

Ng SS. et al, (2007), Nature, 448, 87 - 91

Biochemical characterization of the active heterodimer form of human heparanase (Hpa1) protein expressed in insect cells

McKENZIE E. et al, (2003), Biochemical Journal, 373, 423 - 435

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