Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control
Journal article
Cheng X. et al, (2020), Journal of Clinical Investigation, 130, 2237 - 2251
Genetic basis of oxygen sensing in the carotid body: HIF2α and an isoform switch in cytochrome c oxidase subunit 4
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Bishop T. and Ratcliffe PJ., (2020), Science Signaling, 13, eaba1302 - eaba1302
Systemic silencing of Phd2 causes reversible immune regulatory dysfunction
Journal article
Yamamoto A. et al, (2019), Journal of Clinical Investigation, 129, 3640 - 3656
PHD2 inactivation in Type I cells drives HIF‐2α‐dependent multilineage hyperplasia and the formation of paraganglioma‐like carotid bodies
Journal article
Fielding JW. et al, (2018), The Journal of Physiology, 596, 4393 - 4412
Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2
Journal article
Hulley PA. et al, (2017), The Journal of Pathology, 242, 322 - 333
Hyperplasia and hypertrophy of pulmonary neuroepithelial bodies, presumed airway hypoxia sensors, in hypoxia-inducible factor prolyl hydroxylase-deficient mice
Journal article
Ratcliffe P. et al, (2016), Hypoxia, 69 - 69
Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF‐2 pathway
Journal article
Hodson EJ. et al, (2016), The Journal of Physiology, 594, 1179 - 1195
Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain
Journal article
Chan MC. et al, (2015), PLOS ONE, 10, e0132004 - e0132004
HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine
Journal article
Bishop T. and Ratcliffe PJ., (2015), Circulation Research, 117, 65 - 79
Augmented 5-HT Secretion in Pulmonary Neuroepithelial Bodies from PHD1 Null Mice
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Livermore S. et al, (2015), 309 - 313
Signaling hypoxia by hypoxia-inducible factor protein hydroxylases: a historical overview and future perspectives
Journal article
Peter Ratcliffe P. and Bishop T., (2014), Hypoxia, 197 - 197
Increased frequency and earlier onset of pituitary tumours in mice deleted for a multiple endocrine neoplasia type 1 allele and null for prolyl hydroxylase domain protein 1 (Men1+/-/Phd1-/-)
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Stevenson M. et al, (2014), Endocrine Abstracts
Benefits and risks of manipulating the HIF hydroxylase pathway in ischemic heart disease
Chapter
Bishop T. and Ratcliffe PJ., (2013), Translational Vascular Medicine: Pathogenesis, Diagnosis, and Treatment, 9780857299208, 17 - 25
Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2
Journal article
Bishop T. et al, (2013), The Journal of Physiology, 591, 3565 - 3577
Hyperplasia of pulmonary neuroepithelial bodies (NEB) in lungs of prolyl hydroxylase -1(PHD-1) deficient mice
Journal article
Pan J. et al, (2012), Advances in Experimental Medicine and Biology, 758, 149 - 155
Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice
Journal article
Chen R-L. et al, (2012), The Journal of Physiology, 590, 4079 - 4091
Benefits and Risks of Manipulating the HIF Hydroxylase Pathway in Ischemic Heart Disease
Chapter
Bishop T. and Ratcliffe PJ., (2012), Translational Vascular Medicine, 17 - 25
Loss or Silencing of the PHD1 Prolyl Hydroxylase Protects Livers of Mice Against Ischemia/Reperfusion Injury
Journal article
Schneider M. et al, (2010), Gastroenterology, 138, 1143 - 1154.e2
Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3−/− Mice
Journal article
Bishop T. et al, (2008), Molecular and Cellular Biology, 28, 3386 - 3400
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
Journal article
Aragonés J. et al, (2008), Nature Genetics, 40, 170 - 180