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Publications

Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control

Cheng X. et al, (2020), Journal of Clinical Investigation, 130, 2237 - 2251

Genetic basis of oxygen sensing in the carotid body: HIF2α and an isoform switch in cytochrome c oxidase subunit 4

Bishop T. and Ratcliffe PJ., (2020), Science Signaling, 13, eaba1302 - eaba1302

Systemic silencing of Phd2 causes reversible immune regulatory dysfunction

Yamamoto A. et al, (2019), Journal of Clinical Investigation, 129, 3640 - 3656

PHD2 inactivation in Type I cells drives HIF‐2α‐dependent multilineage hyperplasia and the formation of paraganglioma‐like carotid bodies

Fielding JW. et al, (2018), The Journal of Physiology, 596, 4393 - 4412

Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2

Hulley PA. et al, (2017), The Journal of Pathology, 242, 322 - 333

Hyperplasia and hypertrophy of pulmonary neuroepithelial bodies, presumed airway hypoxia sensors, in hypoxia-inducible factor prolyl hydroxylase-deficient mice

Ratcliffe P. et al, (2016), Hypoxia, 69 - 69

Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF‐2 pathway

Hodson EJ. et al, (2016), The Journal of Physiology, 594, 1179 - 1195

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain

Chan MC. et al, (2015), PLOS ONE, 10, e0132004 - e0132004

HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine

Bishop T. and Ratcliffe PJ., (2015), Circulation Research, 117, 65 - 79

Augmented 5-HT Secretion in Pulmonary Neuroepithelial Bodies from PHD1 Null Mice

Livermore S. et al, (2015), 309 - 313

Signaling hypoxia by hypoxia-inducible factor protein hydroxylases: a historical overview and future perspectives

Peter Ratcliffe P. and Bishop T., (2014), Hypoxia, 197 - 197

Increased frequency and earlier onset of pituitary tumours in mice deleted for a multiple endocrine neoplasia type 1 allele and null for prolyl hydroxylase domain protein 1 (Men1+/-/Phd1-/-)

Stevenson M. et al, (2014), Endocrine Abstracts

Benefits and risks of manipulating the HIF hydroxylase pathway in ischemic heart disease

Bishop T. and Ratcliffe PJ., (2013), Translational Vascular Medicine: Pathogenesis, Diagnosis, and Treatment, 9780857299208, 17 - 25

Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2

Bishop T. et al, (2013), The Journal of Physiology, 591, 3565 - 3577

Hyperplasia of pulmonary neuroepithelial bodies (NEB) in lungs of prolyl hydroxylase -1(PHD-1) deficient mice

Pan J. et al, (2012), Advances in Experimental Medicine and Biology, 758, 149 - 155

Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice

Chen R-L. et al, (2012), The Journal of Physiology, 590, 4079 - 4091

Benefits and Risks of Manipulating the HIF Hydroxylase Pathway in Ischemic Heart Disease

Bishop T. and Ratcliffe PJ., (2012), Translational Vascular Medicine, 17 - 25

Loss or Silencing of the PHD1 Prolyl Hydroxylase Protects Livers of Mice Against Ischemia/Reperfusion Injury

Schneider M. et al, (2010), Gastroenterology, 138, 1143 - 1154.e2

Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3−/− Mice

Bishop T. et al, (2008), Molecular and Cellular Biology, 28, 3386 - 3400

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

Aragonés J. et al, (2008), Nature Genetics, 40, 170 - 180

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