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Publications

Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model

Wing PAC. et al, (2022), PLOS Pathogens, 18, e1010807 - e1010807

Absolute quantitation of individual SARS-CoV-2 RNA molecules provides a new paradigm for infection dynamics and variant differences

Lee JY. et al, (2022), eLife, 11

Silent hypoxaemia in COVID‐19 patients

Simonson TS. et al, (2021), The Journal of Physiology

Hypoxic and Pharmacological Activation of HIF Inhibits SARS-CoV-2 Infection of Lung Epithelial Cells

Wing PAC. et al, (2020), SSRN Electronic Journal

Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control

Cheng X. et al, (2020), Journal of Clinical Investigation, 130, 2237 - 2251

Genetic basis of oxygen sensing in the carotid body: HIF2α and an isoform switch in cytochrome c oxidase subunit 4

Bishop T. and Ratcliffe PJ., (2020), Science Signaling, 13

Systemic silencing of Phd2 causes reversible immune regulatory dysfunction

Yamamoto A. et al, (2019), Journal of Clinical Investigation, 129, 3640 - 3656

PHD2 inactivation in Type I cells drives HIF‐2α‐dependent multilineage hyperplasia and the formation of paraganglioma‐like carotid bodies

Fielding JW. et al, (2018), The Journal of Physiology, 596, 4393 - 4412

Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2

Hulley PA. et al, (2017), The Journal of Pathology, 242, 322 - 333

Hyperplasia and hypertrophy of pulmonary neuroepithelial bodies, presumed airway hypoxia sensors, in hypoxia-inducible factor prolyl hydroxylase-deficient mice

Ratcliffe P. et al, (2016), Hypoxia, 69 - 69

Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF‐2 pathway

Hodson EJ. et al, (2016), The Journal of Physiology, 594, 1179 - 1195

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain

Chan MC. et al, (2015), PLOS ONE, 10, e0132004 - e0132004

HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine

Bishop T. and Ratcliffe PJ., (2015), Circulation Research, 117, 65 - 79

Augmented 5-HT Secretion in Pulmonary Neuroepithelial Bodies from PHD1 Null Mice

Livermore S. et al, (2015), 309 - 313

Signaling hypoxia by hypoxia-inducible factor protein hydroxylases: a historical overview and future perspectives

Peter Ratcliffe P. and Bishop T., (2014), Hypoxia, 197 - 197

Increased frequency and earlier onset of pituitary tumours in mice deleted for a multiple endocrine neoplasia type 1 allele and null for prolyl hydroxylase domain protein 1 (Men1+/-/Phd1-/-)

Stevenson M. et al, (2014), Endocrine Abstracts

Benefits and risks of manipulating the HIF hydroxylase pathway in ischemic heart disease

Bishop T. and Ratcliffe PJ., (2013), Translational Vascular Medicine: Pathogenesis, Diagnosis, and Treatment, 9780857299208, 17 - 25

Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2

Bishop T. et al, (2013), The Journal of Physiology, 591, 3565 - 3577

Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice

Chen R-L. et al, (2012), The Journal of Physiology, 590, 4079 - 4091

Benefits and Risks of Manipulating the HIF Hydroxylase Pathway in Ischemic Heart Disease

Bishop T. and Ratcliffe PJ., (2012), Translational Vascular Medicine, 17 - 25

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