Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model
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Wing PAC. et al, (2022), PLOS Pathogens, 18, e1010807 - e1010807
Absolute quantitation of individual SARS-CoV-2 RNA molecules provides a new paradigm for infection dynamics and variant differences
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Lee JY. et al, (2022), eLife, 11
Silent hypoxaemia in COVID‐19 patients
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Simonson TS. et al, (2021), The Journal of Physiology
Hypoxic and Pharmacological Activation of HIF Inhibits SARS-CoV-2 Infection of Lung Epithelial Cells
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Wing PAC. et al, (2020), SSRN Electronic Journal
Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control
Journal article
Cheng X. et al, (2020), Journal of Clinical Investigation, 130, 2237 - 2251
Genetic basis of oxygen sensing in the carotid body: HIF2α and an isoform switch in cytochrome c oxidase subunit 4
Journal article
Bishop T. and Ratcliffe PJ., (2020), Science Signaling, 13
Systemic silencing of Phd2 causes reversible immune regulatory dysfunction
Journal article
Yamamoto A. et al, (2019), Journal of Clinical Investigation, 129, 3640 - 3656
PHD2 inactivation in Type I cells drives HIF‐2α‐dependent multilineage hyperplasia and the formation of paraganglioma‐like carotid bodies
Journal article
Fielding JW. et al, (2018), The Journal of Physiology, 596, 4393 - 4412
Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2
Journal article
Hulley PA. et al, (2017), The Journal of Pathology, 242, 322 - 333
Hyperplasia and hypertrophy of pulmonary neuroepithelial bodies, presumed airway hypoxia sensors, in hypoxia-inducible factor prolyl hydroxylase-deficient mice
Journal article
Ratcliffe P. et al, (2016), Hypoxia, 69 - 69
Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF‐2 pathway
Journal article
Hodson EJ. et al, (2016), The Journal of Physiology, 594, 1179 - 1195
Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain
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Chan MC. et al, (2015), PLOS ONE, 10, e0132004 - e0132004
HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine
Journal article
Bishop T. and Ratcliffe PJ., (2015), Circulation Research, 117, 65 - 79
Augmented 5-HT Secretion in Pulmonary Neuroepithelial Bodies from PHD1 Null Mice
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Livermore S. et al, (2015), 309 - 313
Signaling hypoxia by hypoxia-inducible factor protein hydroxylases: a historical overview and future perspectives
Journal article
Peter Ratcliffe P. and Bishop T., (2014), Hypoxia, 197 - 197
Increased frequency and earlier onset of pituitary tumours in mice deleted for a multiple endocrine neoplasia type 1 allele and null for prolyl hydroxylase domain protein 1 (Men1+/-/Phd1-/-)
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Stevenson M. et al, (2014), Endocrine Abstracts
Benefits and risks of manipulating the HIF hydroxylase pathway in ischemic heart disease
Chapter
Bishop T. and Ratcliffe PJ., (2013), Translational Vascular Medicine: Pathogenesis, Diagnosis, and Treatment, 9780857299208, 17 - 25
Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2
Journal article
Bishop T. et al, (2013), The Journal of Physiology, 591, 3565 - 3577
Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice
Journal article
Chen R-L. et al, (2012), The Journal of Physiology, 590, 4079 - 4091
Benefits and Risks of Manipulating the HIF Hydroxylase Pathway in Ischemic Heart Disease
Chapter
Bishop T. and Ratcliffe PJ., (2012), Translational Vascular Medicine, 17 - 25