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Publications

Selective regulation of tuft cell-like small cell lung cancer by novel transcriptional co-activators C11orf53 and COLCA2.

Zhou C. et al, (2022), Cell discovery, 8

Structural insights into molecular mechanism for N6-adenosine methylation by MT-A70 family methyltransferase METTL4.

Luo Q. et al, (2022), Nature communications, 13

STAG2 regulates interferon signaling in melanoma via enhancer loop reprogramming.

Chu Z. et al, (2022), Nature communications, 13

Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis.

Xu W. et al, (2022), Molecular cell, 82, 1156 - 1168.e7

Chromatin-state barriers enforce an irreversible mammalian cell fate decision

Blanco MA. et al, (2021), Cell Reports, 37, 109967 - 109967

LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade.

Liu Y. et al, (2021), Nature communications, 12

Simultaneous Inhibition of LSD1 and TGFβ Enables Eradication of Poorly Immunogenic Tumors with Anti-PD-1 Treatment.

Sheng W. et al, (2021), Cancer discovery, 11, 1970 - 1981

Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia.

Zee BM. et al, (2021), iScience, 24

The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands.

Stielow B. et al, (2021), Science advances, 7

Nucleotide resolution profiling of m3C RNA modification by HAC-seq

Cui J. et al, (2021), Nucleic Acids Research, 49, e27 - e27

METTL3 regulates heterochromatin in mouse embryonic stem cells.

Xu W. et al, (2021), Nature, 591, 317 - 321

meCLICK-Seq, a Substrate-Hijacking and RNA Degradation Strategy for the Study of RNA Methylation.

Mikutis S. et al, (2020), ACS central science, 6, 2196 - 2208

METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing

Chen H. et al, (2020), Cell Research, 30, 544 - 547

Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG

Anastas JN. et al, (2019), Cancer Cell, 36, 528 - 544.e10

PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression

Sendinc E. et al, (2019), Molecular Cell, 75, 620 - 630.e9

LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

Sheng W. et al, (2018), Cell, 174, 549 - 563.e19

Polycomb-like proteins link the PRC2 complex to CpG islands

Li H. et al, (2017), Nature, 549, 287 - 291

RNA m6A methylation regulates the ultraviolet-induced DNA damage response

Xiang Y. et al, (2017), Nature, 543, 573 - 576

Suppression of Enhancer Overactivation by a RACK7-Histone Demethylase Complex

Shen H. et al, (2016), Cell, 165, 331 - 342

A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation.

Iwase S. et al, (2016), Cell reports, 14, 1000 - 1009

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